ArticleAtherosclerosis2021
Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study.
Article in Atherosclerosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Not all mental disorders matter equally in peripheral arterial disease: Dementia drives prognosis and care disparities.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Long-Term Association of Cardiovascular Risk Burden With Dementia Risk: The Role of Life-Course Confounders in an Analysis of Cumulative and Specific Factors.Journal of the American Heart Association · 2026Article
- Associations between mid-life social relationships and the risk of incident dementia: The ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from the ARMEX trial.Journal of patient-reported outcomes · 2025Article
- Associations Between Fatigue and Cardiovascular-Kidney-Metabolic Syndrome and the Mediating Role of Inflammation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of social support and health status outcomes in peripheral artery disease.Journal of vascular surgery · 2024Article
- Psychosocial Health and the Association Between Cerebral Small Vessel Disease Markers With Dementia: The ARIC Study.Stroke · 2024Article
- Expanding the Paradigm for Cardiovascular Palliative Care.Circulation · 2023Review
- Depression in Patients with Peripheral Artery Disease: An Underdiagnosis with Increased Mortality.Annals of vascular surgery · 2023Article
- Disease-Specific Quality of Life among Patients with Peripheral Artery Disease in Hungary.International journal of environmental research and public health · 2023Article
- Social isolation in patients with chronic limb-threatening ischemia: a cross-sectional study.Scientific reports · 2023Article
- Social relationships, amyloid burden, and dementia: The ARIC-PET study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsPsychosocial factors are associated with increased risk of cardiovascular disease (CVD). However, associations with peripheral artery disease (PAD) remain uncharacterized. We aimed to compare associations of psychosocial factors with the risk of PAD and two other major atherosclerotic CVD: coronary heart disease (CHD) and ischemic stroke, in the Atherosclerosis Risk in Communities (ARIC) Study.
methodsIn 11,104 participants (mean age 56.7 [SD 5.7] years) without a clinical history of PAD and CHD/stroke at baseline (1990-1992), we evaluated four psychosocial domains: depressive/fatigue symptoms by the Maastricht Questionnaire, social support by the Interpersonal Evaluation List, social networks by the Lubben Scale, and trait anger by the Spielberger Scale. PAD was defined as hospitalizations with diagnosis or related procedures. CHD included adjudicated coronary heart disease and stroke included ischemic stroke.
resultsWe observed 397 PAD and 1940 CHD/stroke events during a median follow-up of 23.1 years. Higher depressive/fatigue symptoms and less social support were significantly associated with incident PAD (adjusted hazard ratios for top vs. bottom quartile 1.65 [95%CI, 1.25-2.19] and 1.40 [1.05-1.87], respectively). When these factors were simultaneously modeled, only depressive/fatigue symptoms remained significant. Incident CHD/stroke was not associated with either of depressive/fatigue symptoms or social support. Social networks and trait anger were not independently associated with PAD or CHD/stroke.
conclusionsDepressive/fatigue symptoms and social support (especially the former) were independently associated with the risk of hospitalizations with PAD but not CHD/stroke in the general population. Our results support the importance of depressive/fatigue symptoms in vascular health and suggest the need of including PAD when studying the impact of psychosocial factors on CVD.
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