Evidence map›Paper›PMID 34020759›Full record

ReviewClinics in laboratory medicine2021

Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape.

Chiranjit Ghosh, Armando Leon, Seena Koshy, Obadah Aloum, Yazan Al-Jabawi, Nour Ismail, Zoe Freeman Weiss, Sophia Koo

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Revolutionizing diagnosis of pulmonaryFrontiers in microbiology · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Systematic comparison of methods for offline breath sampling.Analytical and bioanalytical chemistry · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chiranjit GhoshDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Armando LeonDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Seena KoshyDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Obadah AloumDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Yazan Al-JabawiDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Nour IsmailDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Zoe Freeman WeissDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Sophia KooDivision of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: skoo@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USLemuel Shattuck Hospital · US

Funding

Rapid, Breath Volatile Metabolite-Based Diagnostic for In Vivo Identification and Antibiotic Resistance Profiling of Bacterial Pathogens in Ventilator-Associated PneumoniaR01AI138999 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2018 to 2023
$5.9M
A Rapid Breath Test for Invasive AspergillosisR44AI141264 · NIAID · VOLATYLIX, INC. · PI POGORZELSKI, DONALD E · 2018 to 2021
$3.3M
Breath Volatile Metabolites for the Diagnosis of CoccidioidomycosisR21AI156279 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2021 to 2022
$493k
Rapid Breath-Based Diagnosis of HistoplasmosisR21AI133330 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2017 to 2018
$481k
Aspergillus fumigatus Volatile Secondary Metabolite Dynamics for the Identification of Azole-resistant AspergillosisR21AI130669 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2017 to 2018
$468k
NIAID NIH HHS R01 AI138999NIAID NIH HHS R21 AI130669NIAID NIH HHS R21 AI133330NIAID NIH HHS R21 AI156279NIAID NIH HHS R44 AI141264
6 · The paper itself

Abstract

Various analytical methods can be applied to concentrate, separate, and examine trace volatile organic metabolites in the breath, with the potential for noninvasive, rapid, real-time identification of various disease processes, including an array of microbial infections. Although biomarker discovery and validation in microbial infections can be technically challenging, it is an approach that has shown great promise, especially for infections that are particularly difficult to identify with standard culture and molecular amplification-based approaches. This article discusses the current state of breath analysis for the diagnosis of infectious diseases.

Indexed as

Communicable DiseasesVolatile Organic CompoundsBreath TestsHumansVolatile Organic CompoundsBiomarkerBreathDiagnosisMetabolitesNoninvasivePoint-of-careVOC

Identifiers

PMID34020759
PMCPMC8141093
OpenAlexW3161943411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.