Evidence map›Paper›PMID 34020754›Full record

ArticleArtificial intelligence in medicine2021

Transfer learning in medical image segmentation: New insights from analysis of the dynamics of model parameters and learned representations.

Davood Karimi, Simon K Warfield, Ali Gholipour

Abstract read
In one paragraph

Article in Artificial intelligence in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
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  7. Breaking barriers: noninvasive AI model for BRAFInternational journal of computer assisted radiology and surgery · 2025
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  13. An approach to building foundation models for brain image analysis.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  14. Article
  15. Review
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  20. Augmented reality navigation systems in endoscopy.Frontiers in gastroenterology (Lausanne, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Davood KarimiDepartment of Radiology at Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA. Electronic address: davood.karimi@childrens.harvard.edu.
Simon K WarfieldDepartment of Radiology at Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA.
Ali GholipourDepartment of Radiology at Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA.

Funding

MRI Biomarkers of Patients with Tuberous Sclerosis Complex and AutismR01NS079788 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2013 to 2017
$3.6M
Advancing Microstructural and Vascular Neuroimaging in Perinatal StrokeR01NS106030 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2019 to 2023
$1.7M
Motion-robust super-resolution diffusion weighted MRI of early brain developmentR01EB018988 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI GHOLIPOUR-BABOLI, ALI · 2014 to 2017
$1.6M
NIBIB NIH HHS R01 EB018988NINDS NIH HHS R01 NS079788NINDS NIH HHS R01 NS106030
6 · The paper itself

Abstract

We present a critical assessment of the role of transfer learning in training fully convolutional networks (FCNs) for medical image segmentation. We first show that although transfer learning reduces the training time on the target task, improvements in segmentation accuracy are highly task/data-dependent. Large improvements are observed only when the segmentation task is more challenging and the target training data is smaller. We shed light on these observations by investigating the impact of transfer learning on the evolution of model parameters and learned representations. We observe that convolutional filters change little during training and still look random at convergence. We further show that quite accurate FCNs can be built by freezing the encoder section of the network at random values and only training the decoder section. At least for medical image segmentation, this finding challenges the common belief that the encoder section needs to learn data/task-specific representations. We examine the evolution of FCN representations to gain a deeper insight into the effects of transfer learning on the training dynamics. Our analysis shows that although FCNs trained via transfer learning learn different representations than FCNs trained with random initialization, the variability among FCNs trained via transfer learning can be as high as that among FCNs trained with random initialization. Moreover, feature reuse is not restricted to the early encoder layers; rather, it can be more significant in deeper layers. These findings offer new insights and suggest alternative ways of training FCNs for medical image segmentation.

Indexed as

Image Processing, Computer-AssistedMachine LearningHumansDeep learningFully convolutional neural networksMedical image segmentationTransfer learning

Identifiers

PMID34020754
PMCPMC8164174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.