ArticleDiabetology & metabolic syndrome2021
Gut microbiota changes after metabolic surgery in adult diabetic patients with mild obesity: a randomised controlled trial.
Article in Diabetology & metabolic syndrome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Bariatric Surgery for Adults With Class I Obesity and Difficult-to-Manage Type 2 Diabetes: A Health Technology Assessment.Ontario health technology assessment series · 2023Pooled it
- Short-term gut microbiota's shift after laparoscopic Roux-en-Y vs one anastomosis gastric bypass: results of a multicenter randomized control trial.Surgical endoscopy · 2024Trial
- A review of current evidence and perspectives on the mechanisms and clinical significance of hypoxia-induced remodeling of the gastric microbiota-metabolism axis.Frontiers in microbiology · 2026Review
- Alterations in gut microbial metabolic pathways following bariatric surgery assessed by 16S rRNA gene sequencing.Gut microbiome (Cambridge, England) · 2026Article
- Assessing the impact of bariatric surgery on cardiovascular risk in type 2 diabetes: a systematic review and meta-analysis using OMICs data.Diabetology & metabolic syndrome · 2025Review
- Multi-omics analysis of bariatric surgery's impact on type 2 diabetes and prediabetes.Scientific reports · 2025Article
- Sleeve Gastrectomy and Gastric Bypass Impact in Patient's Metabolic, Gut Microbiome, and Immuno-inflammatory Profiles-A Comparative Study.Obesity surgery · 2025Observational
- The role of gut microbiota in predicting the weight loss following laparoscopic sleeve gastrectomy.Frontiers in microbiology · 2025Article
- Article
- The gut microbiota in obesity and weight management: microbes as friends or foe?Nature reviews. Endocrinology · 2023Review
- Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation.Disease models & mechanisms · 2023Article
- Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Ecological shifts of salivary microbiota associated with metabolic-associated fatty liver disease.Frontiers in cellular and infection microbiology · 2023Article
- Bile acids and microbes in metabolic disease.World journal of gastroenterology · 2022Review
- Microbiota and body weight control: Weight watchers within?Molecular metabolism · 2022Review
- A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Review
- Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era.Gut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of obesity, also improving metabolic and inflammatory status, in patients with mild obesity. The underlying mechanisms have not been fully understood, but gut microbiota is hypothesized to play a key role. Our aim was to evaluate the association between gut microbiota changes and anthropometric, metabolic and inflammatory profiles after metabolic surgery compared with medical therapy, in type 2 diabetic (T2DM) adults with mild obesity (BMI 30-35 kg/m
methodsDM
resultsTwenty patients were included: 10 in surgical and 10 in medical arm. Anthropometric and metabolic comparative analysis favoured RYGB over medical arm. At M12, the percentage of weight loss was 25.5 vs. 4.9% (p < 0.001) and HbA1c was 6.2 vs. 7.7% (p < 0.001) respectively. We observed a continuous increase of genus richness after RYGB up until M12. In the medical arm, genus richness ended-up being significantly lower at M12. Composition analysis indicated significant changes of the overall microbial ecosystem (permanova p = 0.004, [R
conclusionsThis was the first RCT studying composite clinical, analytic, and microbiome changes in T2DM patients with class 1 obesity after RYGB versus standard medical therapy. The remarkable phenotypic improvement after surgery occurred concomitantly with changes in the gut microbiome, but at a lower level.
trial registrationISRCTN53984585.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.