Evidence map›Paper›PMID 34020685›Full record

ArticleFluids and barriers of the CNS2021

Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood-brain barrier and neurovascular unit.

Richard F Keep, Hazel C Jones, Lester R Drewes

Abstract readEditorial
In one paragraph

Article in Fluids and barriers of the CNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Vascularizing the brainiScience · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, 48105, USA. rkeep@umich.edu.
Hazel C JonesGagle Brook House, Chesterton, Bicester, OX26 1UF, UK.
Lester R DrewesDepartment of Biomedical Sciences, University of Minnesota Medical School Duluth, Duluth, MN, 55812, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states impacting the brain barriers and brain fluids; drug delivery to the brain. This editorial also highlights the recently completed Fluids Barriers CNS thematic series entitled, 'Advances in in vitro modeling of the blood-brain barrier and neurovascular unit'. Such in vitro modeling is progressing rapidly.

Indexed as

AnimalsBiomedical ResearchBlood-Brain BarrierBrainCentral Nervous SystemChoroid PlexusGlymphatic SystemHumansHydrocephalusMental DisordersNeurovascular Coupling

Identifiers

PMID34020685
PMCPMC8138848

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.