Evidence map›Paper›PMID 34020453›Full record

ArticleThe American journal of clinical nutrition2021

Human milk 3'-Sialyllactose is positively associated with language development during infancy.

Seoyoon Cho, Ziliang Zhu, Tengfei Li, Kristine Baluyot, Brittany R Howell, Heather C Hazlett, Jed T Elison, Jonas Hauser, Norbert Sprenger, Di Wu and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Seoyoon ChoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7027-0781
Ziliang ZhuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tengfei LiDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kristine BaluyotBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brittany R HowellFralin Biomedical Research Institute at Virginia Tech Carilion (VTC), Department of Human Development and Family Science, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Heather C HazlettDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jed T ElisonInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Jonas HauserNestlé Institute of Health Sciences, Société des Produits Nestlé SA, Lausanne, Switzerland.
Norbert SprengerNestlé Institute of Health Sciences, Société des Produits Nestlé SA, Lausanne, Switzerland.ORCID 0000-0003-4880-2750
Di WuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-8331-2357
Weili LinDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USNestlé (Switzerland) · CHBiomedical Research Institute · USUniversity of Minnesota · US

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32MH015755 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Megan R Gunnar · 1985 to 2026
$5.9M
UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Infant Brain and Behavioral Signatures of Later Emerging Risk for PsychopathologyR01MH104324 · NIMH · UNIVERSITY OF MINNESOTA · PI ELISON, JED THOMAS · 2014 to 2018
$2.6M
NICHD NIH HHS R01 HD055741NIH HHS U01MH110274NIMH NIH HHS R01 MH104324NIMH NIH HHS T32 MH015755NIMH NIH HHS U01 MH110274
6 · The paper itself

Abstract

backgroundGenetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.

objectivesThis study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old).

methodsWe enrolled typically developing children (2-25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning (MSEL) were used as the primary outcome measure to assess early cognitive development. Linear mixed effects models were employed by stratifying children based on A-tetra levels (A-tetra+ or A-tetra-) to assess associations between age-removed HMO concentrations and both MSEL composite scores and the 5 subdomain scores.

resultsA total of 99 mother-child dyads and 183 HM samples were included (A-tetra+: 57 samples, 33 dyads; A-tetra-: 126 samples, 66 dyads). No significant association was observed between HMOs and MSEL when all samples were analyzed together. The composite score and 3'-sialyllactose (3'-SL) levels were positively associated [P = 0.002; effect size (EF), 13.12; 95% CI, 5.36-20.80] in the A-tetra + group. This association was driven by the receptive (adjusted P = 0.015; EF, 9.95; 95% CI, 3.91-15.99) and expressive (adjusted P = 0.048; EF, 7.53; 95% CI, 2.51-13.79) language subdomain scores. Furthermore, there was an interaction between 3'-SL and age for receptive language (adjusted P = 0.03; EF, -14.93; 95% CI, -25.29 to -4.24).

conclusionsOur study reports the association of 3'-SL and cognition, particularly language functions, in typically developing children who received HM containing detectable A-tetra during infancy.

Indexed as

Language DevelopmentAdultBreast FeedingChild, PreschoolFemaleHumansInfantMilk, HumanOligosaccharides3'-sialyllactoseOligosaccharidesbreastfed infantsearly cognitive developmenthuman milkhuman milk oligosaccharideslanguageMullen Scales of Early Learningrandom linear mixed effects modelsialyllactose

Identifiers

PMID34020453
PMCPMC8326052
OpenAlexW3162374871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.