Evidence map›Paper›PMID 34019950›Full record

ArticleAntiviral research2021

Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogs.

Joyce Sweeney Gibbons, Sudip Khadka, Caroline G Williams, Lin Wang, Stewart W Schneller, Chong Liu, JoAnn M Tufariello, Christopher F Basler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joyce Sweeney GibbonsCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
Sudip KhadkaCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Caroline G WilliamsCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Lin WangCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Stewart W SchnellerMolette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, USA.
Chong LiuMolette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, USA.
JoAnn M TufarielloCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Christopher F BaslerCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. Electronic address: cbasler@gsu.edu.
Georgia State University · USAuburn University · USMayo Clinic · US

Funding

Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
Small Molecule Inhibitors of Ebola Virus Polymerase FunctionR01AI125453 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2017 to 2021
$4.3M
NIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI125453
6 · The paper itself

Abstract

3-deazaneplanocin A (DzNep) and its 3-brominated analogs inhibit replication of several RNA viruses. This antiviral activity is attributed to inhibition of S-adenosyl homocysteine hydrolase (SAHase) and consequently inhibition of viral methyltransferases, impairing translation of viral transcripts. The L-enantiomers of some derivatives retain antiviral activity despite dramatically reduced inhibition of SAHase in vitro. To better understand the mechanisms by which these compounds exert their antiviral effects, we compared DzNep, its 3-bromo-derivative, CL123, and the related enantiomers, CL4033 and CL4053, for their activities towards the model negative-sense RNA virus vesicular stomatitis virus (VSV). In cell culture, DzNep, CL123 and CL4033 each exhibited 50 percent inhibitory concentrations (IC50s) in the nanomolar range whereas the IC50 for the L-form, CL4053, was 34-85 times higher. When a CL123-resistant mutant (VSV

Indexed as

AdenosineAnimalsAntiviral AgentsChlorocebus aethiopsInhibitory Concentration 50MethylationProtein BiosynthesisProtein Synthesis InhibitorsTranscription, GeneticVero CellsVesicular stomatitis Indiana virusVirus Replication3-deazaneplanocinAdenosineAntiviral AgentsProtein Synthesis InhibitorsNeplanocinS-adenosyl homocysteine hydrolaseVesicular stomatitis virusViral transcription

Identifiers

PMID34019950
PMCPMC8244617
OpenAlexW3163925125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.