Evidence map›Paper›PMID 34019918›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer.

Umesh Mahantshetty, Richard Poetter, Sushil Beriwal, Surbhi Grover, Gurram Lavanya, Bhavana Rai, Primoz Petric, Kari Tanderup, Heloisa Carvalho, Neamat Hegazy and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07249021 (Integration of Multi-modality Imaging Protocols With emphAsis on CT in Image Guided Adaptive Brachytherapy), which is not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07249021 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Integration of Multi-modality Imaging Protocols With emphAsis on CT in Image Guided Adaptive Brachytherapy (IGABT) for Cervical Cancer - EMBRACE III-IMPACT STUDY

TypeobservationalSponsorHomi Bhabha Cancer Hospital & Research CentreRan2025 to 2031Enrolled1,200ConditionsLocally Advanced Cervical Cancer, Brachytherapy, CT, Transrectal UltrasoundArmsCT IGABT
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. AAPM medical physics practice guideline 13.a: HDR brachytherapy, part B.Journal of applied clinical medical physics · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The impact of uterine position during brachytherapy on treatment outcomes and toxicity in patients with cervical cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Which is the best timing to assess response after chemoradiation in locally advanced cervical cancer (BRILACC)?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Dose contribution from brachytherapy to the pelvic lymph nodal region during HDR image-guided brachytherapy - a study for rethinking modern volume-based planning.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Article
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Umesh MahantshettyDirector and Professor, Radiation Oncology Homi Bhabha Cancer Hospital and Research Centre (A Unit of Tata Memorial Centre, Mumbai), Visakhapatnam, India. Electronic address: drumeshm@gmail.com.
Richard PoetterMedical University of Vienna, Department of Radiation Oncology-Comprehensive Cancer Center, Vienna, Austria. Electronic address: Richard.Poetter@akhwien.at.
Sushil BeriwalUPMC Hillman Cancer Center, Pittsburgh, USA.
Surbhi GroverDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia USA and Botswana-UPENN Partnership, Gaborone, Botswana.
Gurram LavanyaDepartment of Radiation Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Bhavana RaiDepartment of Radiotherapy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Primoz PetricDepartment of Radiation Oncology University Hospital Zürich, Switzerland.
Kari TanderupDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Heloisa CarvalhoDepartment of Radiology and Oncology, Radiotherapy Division, University of São Paulo, São Paulo, Brazil; Department of Radiotherapy, Hospital Sírio-Libanês, São Paulo, Brazil.
Neamat HegazyDepartment of Clinical Oncology and Nuclear Medicine, Alexandria University, Egypt.
Sandy MohamedDepartment of Radiotherapy and Nuclear Medicine, NCI, Cairo University, Egypt.
Tatsuya OhnoDepartment of Radiation Oncology, Gunma University Graduate School of Medicine, Japan.
Napapat AmornwichetDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Funding

Prognostic value of quantitative HPV viral load in determining cervical cancer treatment response and recurrenceK08CA230170 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GROVER, SURBHI · 2019 to 2023
$1.4M
NCI NIH HHS K08 CA230170
6 · The paper itself

Abstract

MR Imaging is regarded asthe gold standardfor Image Gudied Adaptive Brachytherapy (IGABT) for cervical cancer. However, its wide applicability is limited by its availability, logistics and financial implications. Use of alternative imaging like CTand Ultrasound (US) for IGABT has been attempted. In order to arrive at a systematic, uniform and international approach for CT based definition and contouring of target structures, GEC ESTRO, IBS and ABS agreed to jointly develop such recommendations based on the concepts and terms as published in the ICRU Report 89. The minimum requirements are clinical examination & documentation, CT or MR imaging at diagnosis and at a minimum, CT imaging with the applicator in place. The recommendations are based on (i) assessment of the GTV at diagnosis and at brachytherapy, (ii) categorizing the response to external radiation into different clinical remission patterns, (iii) defining various clinico-radiological environments and (iv) definition & delineation of a target on CT imaging at the time of brachytherapy with the applicator in situ. CT based target contouring recommendations based on 4 remission categories within 8 defined environments, aim at improving the contouring accuracy for IGABT using CT, US and MRI as available. For each clinico-radiological environment, there is an attempt to minimize the specific uncertainties in order to arrive at the best possible contouring accuracy. Evaluating feasibility & reproducibility, to achieve a benchmark towards a gold standard MR IGABT and further clinical research including outcomes with CT Based IGABT will become the next steps.

Indexed as

BrachytherapyUterine Cervical NeoplasmsFemaleHumansMagnetic Resonance ImagingReproducibility of ResultsTomography, X-Ray ComputedCervical cancerCervical cancer brachytherapy recommendationsCT based contouringCT environmentsIGABT

Identifiers

PMID34019918
PMCPMC8675891

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.