ArticleCell metabolism2021
Adhesion-mediated mechanosignaling forces mitohormesis.
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Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92citing papers in PubMed
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Who cites it
92 citing papers in PubMed, 133 citations in OpenAlex.
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- Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA-dependent immunity in breast cancer.Nature communications · 2026Article
- Stretch strain shifts optic nerve head astrocyte metabolism to enrich α-ketoglutarate and the pentose phosphate pathway.Scientific reports · 2026Article
- Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.Cell death & disease · 2026Article
- Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress.Advanced genetics (Hoboken, N.J.) · 2026Article
- The Emerging Role of Mechanobiology in Connecting Metabolic and Cardiovascular Diseases: From Fundamentals to Future Therapies.Biomedicines · 2026Review
- Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-Derived Midbody Remnant Proteome Following Epithelial-Mesenchymal Transition.Proteomics · 2026Article
- Mechanical regulation of metabolism, epigenetics, and their interplay.npj biomedical innovations · 2026Review
- Ionic Regulation of Mechanosurveillance and Metastasis via the MRTFA/KCNMB1 Axis.bioRxiv : the preprint server for biology · 2026Article
- The spectrum of pregnancy-induced cardiac remodeling: transitioning from healthy adaptive hypertrophy to peripartum cardiomyopathy.Frontiers in cell and developmental biology · 2026Review
- Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025Article
- FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation.Disease models & mechanisms · 2025Article
- An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration.Experimental & molecular medicine · 2025Review
- Cross-comparison of strains used for mitochondrial imaging inLife science alliance · 2025Article
- Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing.Bioactive materials · 2025Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 7 institutions in 1 country.
Kevin M TharpCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Ryo Higuchi-SanabriaDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94597, USA.
Greg A TimblinDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Breanna FordDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA; Novartis, Berkeley Center for Proteomics and Chemistry Technologies and Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA.
Carlos Garzon-CoralChemical Engineering Department, Stanford University, Stanford, CA 94305, USA.
Catherine SchneiderNovartis, Berkeley Center for Proteomics and Chemistry Technologies and Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA.
Jonathon M MuncieCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Connor StashkoCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Joseph R DanieleMD Anderson Cancer Center, South Campus Research, Houston, CA 77054, USA.
Andrew S MooreJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Phillip A FrankinoDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94597, USA.
Stefan HomentcovschiDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94597, USA.
Sagar S ManoliDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Hao ShaoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Alicia L RichardsQuantitative Biosciences Institute (QBI), J. David Gladstone Institutes, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Kuei-Ho ChenQuantitative Biosciences Institute (QBI), J. David Gladstone Institutes, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Johanna Ten HoeveUCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Gregory M KuDiabetes Center, Division of Endocrinology and Metabolism, Department of Medicine, UCSF, San Francisco, CA 94143, USA.
Marc HellersteinNovartis, Berkeley Center for Proteomics and Chemistry Technologies and Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA.
Daniel K NomuraDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA; Novartis, Berkeley Center for Proteomics and Chemistry Technologies and Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA.
Karou SaijoDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Jason GestwickiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Alexander R DunnDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA.
Nevan J KroganQuantitative Biosciences Institute (QBI), J. David Gladstone Institutes, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Danielle L SwaneyQuantitative Biosciences Institute (QBI), J. David Gladstone Institutes, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Andrew DillinDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94597, USA.
Valerie M WeaverCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and The Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: valerie.weaver@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · USHoward Hughes Medical Institute · USGladstone Institutes · USStanford University · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, Los Angeles · US
Funding
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4MProject 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI CANTLEY, LEWIS C., FISCHBACH, CLAUDIA · 2016 to 2020
$10.2MMolecular Chaperones and Small MoleculesR01NS059690 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason E Gestwicki · 2008 to 2026
$7.9MTissue mechanics reprograms the tissue to malignancy and metastasisR35CA242447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALERIE MARIE WEAVER · 2020 to 2026
$6.6MMolecular mechanisms underlying force transduction at cellular adhesion complexesR35GM130332 · NIGMS · STANFORD UNIVERSITY · PI Alexander R Dunn · 2019 to 2026
$4.9MProteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic MechanismsRF1AG059751 · NIA · J. DAVID GLADSTONE INSTITUTES · PI KROGAN, NEVAN J, MAHLEY, ROBERT W. · 2019 to 2019
$4.7MTension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9MTissue Tension, RANK and Breast Cancer RiskR01CA222508 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HWANG, E.SHELLEY, WEAVER, VALERIE MARIE · 2018 to 2022
$2.8MThe Collapse of Proteostasis during Aging is Mediated by Cytoskeletal Actin FunctionsR01AG055891 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2017 to 2021
$1.6MQuantitative Mass Spectrometer for Targeted and Global Proteomics, MetabolomicsS10OD016387 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRAEBER, THOMAS G · 2013 to 2013
$593kMore than just a load control: cytoskeletal form and function during agingK99AG065200 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2020 to 2021
$244kMechanical stress reprograms mitochondrial metabolism to support tumor survival and invasion through the mitochondrial unfolded protein responseF32CA236156 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THARP, KEVIN · 2019 to 2021
$110kHoward Hughes Medical InstituteNCI NIH HHS F32 CA236156NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA222508NCI NIH HHS R35 CA242447NCI NIH HHS T32 CA108462NCI NIH HHS U54 CA210184NIA NIH HHS K99 AG065200NIA NIH HHS R01 AG055891NIA NIH HHS RF1 AG059751NIGMS NIH HHS R35 GM130332NIH HHS S10 OD016387NINDS NIH HHS R01 NS059690
Abstract
Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of aging. However, the physical characteristics of the extracellular matrix are also altered in cancerous and aging tissues. Here, we demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via solute carrier family 9 member A1-dependent ion exchange and heat shock factor 1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer.
Indexed as
AdultAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCell AdhesionCell RespirationCells, CulturedExtracellular MatrixFemaleHEK293 CellsHumansHyperglycemiaIntegrinsIon ExchangeMechanotransduction, CellularMiceIntegrinsReactive Oxygen SpeciesSodium-Hydrogen Exchanger 1adhesionagingcancerextracellular matrixmechanical stressmechanotabolismmetabolismoxidative stresstensionUPRmt
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