Evidence map›Paper›PMID 34019810›Full record

ArticleNeuron2021

Decision-making ability, psychopathology, and brain connectivity.

Michael Moutoussis, Benjamín Garzón, Sharon Neufeld, Dominik R Bach, Francesco Rigoli, Ian Goodyer, Edward Bullmore, NSPN Consortium, Marc Guitart-Masip, Raymond J Dolan

Abstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
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  7. Article
  8. Article
  9. Dorsal-Ventral Reinforcement Learning Network Connectivity and Incentive-Driven Changes in Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  19. From Computation to Clinic.Biological psychiatry global open science · 2023
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Michael MoutoussisWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, UK; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK. Electronic address: m.moutoussis@ucl.ac.uk.
Benjamín GarzónAging Research Centre, Karolinska Institute, Stockholm, Sweden.
Sharon NeufeldDepartment of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.
Dominik R BachWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, UK; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK; Computational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland.
Francesco RigoliDepartment of Psychology, City University, London, UK.
Ian GoodyerDepartment of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.
Edward BullmoreDepartment of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.
NSPN Consortium
Marc Guitart-MasipMax Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK; Aging Research Centre, Karolinska Institute, Stockholm, Sweden.
Raymond J DolanWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, UK; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK.

Funding

Department of HealthMedical Research Council MC_G0802534Wellcome TrustWellcome Trust 095844/7/11/ZWellcome Trust 098362/Z/12/Z
6 · The paper itself

Abstract

Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask whether a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call "decision acuity," which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decision acuity and IQ had dissociable brain signatures, in terms of their associated neural networks of resting-state functional connectivity. Decision acuity was reliably measured, and its relationship with functional connectivity was also stable when measured in the same individuals 18 months later. Thus, our behavioral and brain data identify a new cognitive construct that underpins decision-making ability across multiple domains. This construct may be important for understanding mental health, particularly regarding poor social function and aberrant thought patterns.

Indexed as

Psychosocial FunctioningSocial InteractionAdolescentAffectAntisocial Personality DisorderAnxietyBrainCognitionDecision MakingDepressionFactor Analysis, StatisticalFemaleFunctional NeuroimagingHumansIntelligence TestsMagnetic Resonance Imagingadolescencecomputational psychiatrydecision acuitydevelopmentfunctional connectivity

Identifiers

PMID34019810
PMCPMC8221811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.