Evidence map›Paper›PMID 34019786›Full record

ArticleMolecular cell2021

A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks.

Pierre Caron, Enrico Pobega, Sophie E Polo

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epigenetic Regulation of Nucleotide Excision Repair.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Pierre CaronLaboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France.
Enrico PobegaLaboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France.
Sophie E PoloLaboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France. Electronic address: sophie.polo@univ-paris-diderot.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a barcoded reporter introduced within a thousand different chromatin locations in human cells, (Schep et al., 2021) characterize repair outcomes of Cas9-induced DNA double-strand breaks (DSBs) and the relative use of DSB repair pathways depending on the local chromatin context.

Indexed as

ChromatinDNA Breaks, Double-StrandedCRISPR-Cas SystemsDNADNA RepairHumansChromatinDNA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.