Evidence map›Paper›PMID 34019703›Full record

ArticleJournal of medical virology2021

Evaluation of the relationship between KIM-1 and suPAR levels and clinical severity in COVID-19 patients: A different perspective on suPAR.

Buğra Kerget, Ferhan Kerget, Alperen Aksakal, Seda Aşkın, Elif Yılmazel Uçar, Leyla Sağlam

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Is Extracorporeal Membrane Oxygenation a Panacea?The Eurasian journal of medicine · 2023
    Article
  10. Article
  11. Article
  12. SARS-CoV-2 Infection and Candidate Biomarkers.The Eurasian journal of medicine · 2022
    Article
  13. Article
  14. Review
  15. suPAR: An Inflammatory Mediator for Kidneys.Kidney diseases (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Buğra KergetDepartment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-6048-1462
Ferhan KergetDepartment of Infection Diseases and Clinical Microbiology, Health Sciences University Erzurum Regional Education and Research Hospital, Yakutiye, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-5160-4854
Alperen AksakalDepartment of Pulmonary Diseases, Health Sciences University Erzurum Regional Education and Research Hospital, Yakutiye, Erzurum, Turkey.ORCID http://orcid.org/0000-0001-6883-3314
Seda AşkınDepartment of Biochemistry, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.ORCID https://orcid.org/0000-0001-6133-9065
Elif Yılmazel UçarDepartment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.ORCID https://orcid.org/0000-0001-8284-1038
Leyla SağlamDepartment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.ORCID https://orcid.org/0000-0002-7040-3433
Atatürk University · TRErzurum Regional Training and Research Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is one of the most pressing health problems of this century, but our knowledge of the disease is still limited. In this study, we aimed to examine serum-soluble urokinase plasminogen activator receptor (suPAR) and kidney injury molecule 1 (KIM-1) levels based on the clinical course of COVID-19. Our study included 102 patients over the age of 18 who were diagnosed as having COVID-19 between September 2020 and December 2020 and a control group of 50 health workers over the age of 18 whose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR results were negative. KIM-1 was measured by ELISA and suPAR by suPARnostic™ assay. Analysis of previously identified variables of prognostic significance in COVID-19 revealed high neutrophil to lymphocyte ratio, lactose dehydrogenase, prothrombin time, C-reactive protein, PaO

Indexed as

SARS-CoV-2AdultAgedBiomarkersCOVID-19FemaleHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedMultivariate AnalysisPrognosisReceptors, Urokinase Plasminogen ActivatorSeverity of Illness IndexBiomarkersHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1PLAUR protein, humanReceptors, Urokinase Plasminogen ActivatorCOVID-19KIM-1suPAR

Identifiers

PMID34019703
PMCPMC8242801
OpenAlexW3161821408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.