ArticleNucleic acids research2021
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights.
Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2,179 papers.
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Who cites it
2,179 citing papers in PubMed.
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- A targeted metabolic intervention via exercise applied after vaccination shapes kinetics and durability of serum antibody accompanied by a distinct immunometabolic signature: pilot study.Brain, behavior, & immunity - health · 2026Article
- Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Molecular and metabolic drivers of oil quality and bioenergy potential in Jatropha curcas.Planta · 2026Article
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- The Integrated Management of Sugar-Beet Soilborne Diseases Through Rhizosphere Microbiome Strategies: A Critical Review of Agronomic Evidence and Application Gaps.Plants (Basel, Switzerland) · 2026Review
- Assembling an Expanded Metabolome for Camu-Camu (Myrciaria Dubia): Bioactive and Nutritional Compounds Relevant to Functional Food Research.Molecules (Basel, Switzerland) · 2026Article
- Urinary Volatilomic Profiling Reveals Candidate Metabolomic Signatures Associated with Colorectal Cancer.Biology · 2026Article
- Dimensionality reduction and metabolite panel derivation in urinary metabolomics based on Random Forest with Gini index feature selection.Analytical and bioanalytical chemistry · 2026Article
- Impact of aging on neck vasculature and brain biochemistry in female mice.Physiological reports · 2026Article
- Targeting CD44 reverses sphingomyelin-induced oligodendrocyte maturation arrest in acid sphingomyelinase deficiency.EMBO molecular medicine · 2026Article
- Breath volatiles reflect diabetic gastroparesis and its recovery by activating NaExperimental & molecular medicine · 2026Article
2,119 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
Since its first release over a decade ago, the MetaboAnalyst web-based platform has become widely used for comprehensive metabolomics data analysis and interpretation. Here we introduce MetaboAnalyst version 5.0, aiming to narrow the gap from raw data to functional insights for global metabolomics based on high-resolution mass spectrometry (HRMS). Three modules have been developed to help achieve this goal, including: (i) a LC-MS Spectra Processing module which offers an easy-to-use pipeline that can perform automated parameter optimization and resumable analysis to significantly lower the barriers to LC-MS1 spectra processing; (ii) a Functional Analysis module which expands the previous MS Peaks to Pathways module to allow users to intuitively select any peak groups of interest and evaluate their enrichment of potential functions as defined by metabolic pathways and metabolite sets; (iii) a Functional Meta-Analysis module to combine multiple global metabolomics datasets obtained under complementary conditions or from similar studies to arrive at comprehensive functional insights. There are many other new functions including weighted joint-pathway analysis, data-driven network analysis, batch effect correction, merging technical replicates, improved compound name matching, etc. The web interface, graphics and underlying codebase have also been refactored to improve performance and user experience. At the end of an analysis session, users can now easily switch to other compatible modules for a more streamlined data analysis. MetaboAnalyst 5.0 is freely available at https://www.metaboanalyst.ca.
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