Evidence map›Paper›PMID 34019568›Full record

ArticlePloS one2021

Outcomes of retained and disengaged pregnant women living with HIV in Uganda.

Agnes N Kiragga, Ellon Twinomuhwezi, Grace Banturaki, Marion Achieng, Juliet Nampala, Irene Bagaya, Joanita Kigozi, Barbara Castelnuovo, Beverly S Musick, Rohan Hazra and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
  6. Prevention of mother-to-child transmission of HIV service interruptions amid COVID-19 pandemic.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Agnes N KiraggaResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0002-0969-0699
Ellon TwinomuhweziResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Grace BanturakiResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Marion AchiengResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Juliet NampalaResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Irene BagayaResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Joanita KigoziResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Barbara CastelnuovoResearch Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Beverly S MusickSchool of Medicine, Indiana University, Indianapolis, Indiana, United States of America.
Rohan HazraNational Institute of Child Health and Human Development (NICHD), National Institutes for Health, Bethesda, MD, United States of America.
Constantin T YiannoutsosFairbanks School of Public Health, Indiana University, Indianapolis, Indiana, United States of America.
Kara K Wools-KaloustianSchool of Medicine, Indiana University, Indianapolis, Indiana, United States of America.
Infectious Diseases Institute · UGIndiana University – Purdue University Indianapolis · USEunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
FIC NIH HHS D43 TW009771NIAID NIH HHS U01 AI069911
6 · The paper itself

Abstract

introductionLoss-to-follow-up among women living with HIV (WLWHIV) may lead to unfavorable outcomes for both mother and exposed infant. This study traced WLWHIV disengaged from care and their infants and compared their outcomes with those retained in care.

methodsThe study included WLWHIV who initiated ART during pregnancy at six public clinics in Uganda. A woman was defined as disengaged (DW) if she had not attended her 6-week post-partum visit by 10 weeks after her estimated date of delivery. DW were matched with retained women (RW) by age and duration on ART. Nurse counselors traced all selected DW via telephone and community visits to assess vital status, infant HIV sero-status and maternal HIV viral load through blood draws.

resultsBetween July 2017 and July 2018, 734 women (359 DW and 375 RW) were identified for the study. Tracing was attempted on 349 DW and 160 (44.6%) were successfully located and enrolled in the study. They were matched with 162 RW. Among DW, 52 (32.5%) transferred to another health facility. Very few DW, 39.0% were HIV virally suppressed (<1000 copies/ml) compared to RW 89.5%, P<0.001). Among 138 babies born to DW, 4.3% tested positive for HIV compared to 1.4% among babies born to RW (P = 0.163).

conclusionPregnant and breastfeeding WLWHIV who disengage from care are difficult to find in urban environments. Many have detectable viral loads, leading to the potential for an increased risk of MTCT. Efforts to reduce disengagement from care are critical for the successful elimination of MTCT in resource-limited settings.

Indexed as

AdultBreast FeedingFemaleHIV InfectionsHumansPostpartum PeriodPregnancyPregnancy Complications, InfectiousPregnant PeopleUgandaViral LoadYoung Adult

Identifiers

PMID34019568
PMCPMC8139492
OpenAlexW3161566578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.