Evidence map›Paper›PMID 34019498›Full record

SynthesisJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2021

Reporting and Analyzing Race and Ethnicity in Orthopaedic Clinical Trials: A Systematic Review.

Ryan W Paul, Donghoon Lee, Joseph Brutico, Fotios P Tjoumakaris, Michael G Ciccotti, Kevin B Freedman

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Race, ethnicity, and language are underreported in hip fracture CPGs.Archives of orthopaedic and trauma surgery · 2026
    Review
  5. Racial and Ethnic Representation Reporting in Orthopaedic Research.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan W PaulFrom the Rothman Institute Orthopaedics, Thomas Jefferson University Hospital, Philadelphia, PA.ORCID 0000-0002-6846-3349
Joseph Brutico
Fotios P TjoumakarisORCID 0000-0002-1013-7735
Michael G CiccottiORCID 0000-0002-8873-2219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe distinction between race and ethnicity should be carefully understood and described for demographic data collection. Racial healthcare differences have been observed across many orthopaedic subspecialties. However, the frequency of reporting and analyzing race and ethnicity in orthopaedic clinical trials has not been determined. Therefore, the primary purpose of this systematic review was to determine how frequently race and ethnicity are reported and analyzed in orthopaedic clinical trials.

methodsThe top 10 journals by impact factor in the field of orthopaedics were manually screened from 2015 to 2019. All randomized controlled trials related to orthopaedics and assessing clinical outcomes were included. Eligible studies were evaluated for bias using the Cochrane risk-of-bias tool and for whether the trial reported and analyzed several demographics, including age, sex, height, weight, race, and ethnicity. The frequency of reporting and analyzing by each demographic was accessed. In addition, comparisons of reporting and analyzing race/ethnicity were made based on orthopaedic subspecialty and journal of publication.

resultsA total of 15,488 publications were screened and 482 met inclusion criteria. Of these 482 trials, 460 (95.4%) reported age and 456 (94.6%) reported sex, whereas 35 (7.3%) reported race and 15 (3.1%) reported ethnicity for the randomized groups; 79 studies (16.4%) analyzed age and 72 studies (14.9%) analyzed sex, whereas 6 studies (1.2%) analyzed race and 1 study (0.2%) analyzed ethnicity. The orthopaedic subspecialty of spine was found to report race (23.5%) and ethnicity (17.6%) more frequently than all the other subspecialties, whereas sports medicine reported race and/or ethnicity in only 3 of 150 trials (2.0%).

conclusionsRace and ethnicity are not frequently reported or analyzed in orthopaedic randomized controlled trials. Social context, personal challenges, and economic challenges should be considered while analyzing the effect of race and ethnicity on outcomes.

Indexed as

Orthopedic ProceduresOrthopedicsAgedBiasData CollectionEthnicityHumans

Identifiers

PMID34019498
PMCPMC8143759

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.