Evidence map›Paper›PMID 34019369›Full record

ArticleACS chemical biology2021

Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms.

Yan Yu, Ying K Zhang, Murli Manohar, Alexander B Artyukhin, Anshu Kumari, Francisco J Tenjo-Castano, Hung Nguyen, Pratyush Routray, Andrea Choe, Daniel F Klessig and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Interactions Between Bacterivorous Nematodes and Bacteria Reduce NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. The fate of enterohemorrhagicFood bioscience · 2024
    Article
  8. Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yan YuBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Ying K ZhangBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Murli ManoharBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Alexander B ArtyukhinChemistry Department, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210, United States.
Anshu KumariBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Francisco J Tenjo-CastanoBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Hung NguyenHoloclara, Inc., Pasadena, California 91101, United States.
Pratyush RoutrayDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Andrea ChoeHoloclara, Inc., Pasadena, California 91101, United States.
Daniel F KlessigBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.
Frank C SchroederBoyce Thompson Institute, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-4420-0237
Cornell University · USState University of New York · US

Funding

Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
Small Molecule Signaling in Caenorhabditis elegansR01GM088290 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI SCHROEDER, FRANK CLEMENS · 2010 to 2017
$2.2M
Starvation-induced social behavior in C. elegansR01GM113692 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI SCHROEDER, FRANK CLEMENS · 2016 to 2018
$1.1M
NIGMS NIH HHS R01 GM088290NIGMS NIH HHS R01 GM113692NIGMS NIH HHS R35 GM131877
6 · The paper itself

Abstract

Many bacterivorous and parasitic nematodes secrete signaling molecules called ascarosides that play a central role regulating their behavior and development. Combining stable-isotope labeling and mass spectrometry-based comparative metabolomics, here we show that ascarosides are taken up from the environment and metabolized by a wide range of phyla, including plants, fungi, bacteria, and mammals, as well as nematodes. In most tested eukaryotes and some bacteria, ascarosides are metabolized into derivatives with shortened fatty acid side chains, analogous to ascaroside biosynthesis in nematodes. In plants and

Indexed as

AnimalsBacteriaCaenorhabditis elegansGlycolipidsMetabolomicsMicePlantsRatsSignal Transductionascaroside AGlycolipids

Identifiers

PMID34019369
PMCPMC8590397
OpenAlexW3161507597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.