Evidence map›Paper›PMID 34019336›Full record

ArticlePediatric blood & cancer2021

Testicular thrombotic microangiopathy: An unrecognized complication.

Anthony Sabulski, Sara Szabo, Kasiani C Myers, Stella M Davies, Sonata Jodele

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anthony SabulskiDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-3652-0003
Sara SzaboDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kasiani C MyersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-5528-4405
Stella M DaviesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-3137-6647
Sonata JodeleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-1791-7718
Cincinnati Children's Hospital Medical Center · US

Funding

Thrombotic microangiopathy (TMA) associated MODS after stem cell transplantationR01HD093773 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI JODELE, SONATA · 2018 to 2021
$2.8M
NICHD NIH HHS R01 HD093773
6 · The paper itself

Abstract

Thrombotic microangiopathy (TMA) causes global endothelial damage and multiorgan injury. No study has described reproductive organ involvement in TMA. Our study aimed to characterize testicular involvement in TMA. We reviewed autopsies from four patients who underwent hematopoietic cell transplant (HCT) complicated by TMA. Three patients had striking histologic evidence of TMA, while the fourth had normal testicular histology. This suggests that TMA injures the testicles and may adversely affect fertility. There is now an urgent need for a larger analysis of reproductive organ involvement in TMA.

Indexed as

Hematopoietic Stem Cell TransplantationThrombotic MicroangiopathiesHumansMaleMultiple Organ FailureTestisfertilityhematopoietic cell transplantthrombotic microangiopathyvascular biology

Identifiers

PMID34019336
PMCPMC8483594
OpenAlexW3160736251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.