Evidence map›Paper›PMID 34019295›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.

Joanna R Kovalski, Yichen Xu, Davide Ruggero

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joanna R Kovalski *Department of Urology, University of California, San Francisco, San Francisco, CA, USA. Joanna.Kovalski@ucsf.edu.
Yichen Xu *Department of Urology, University of California, San Francisco, San Francisco, CA, USA. Yichen.Xu@ucsf.edu.
Davide RuggeroDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A central component of Myc's role as a master coordinator of energy metabolism and biomass accumulation is its ability to increase the rate of protein synthesis, driving cell cycle progression, and proliferation. Importantly, Myc-induced alterations in both global and specific mRNA translation is a key determinant of Myc's oncogenic function. Herein, we provide five assays to enable researchers to measure global protein synthesis changes, to identify the translatome uniquely regulated by Myc and to investigate the mechanisms generating the tailored Myc translation network. Metabolic labeling of cells with

Indexed as

Cell Transformation, NeoplasticDNAGene Expression Regulation, NeoplasticGenes, mycHomeostasisHumansMetabolomicsNeoplasmsProtein BiosynthesisProteinsProto-Oncogene Proteins c-mycRibosomesRNA, MessengerDNAProteinsProto-Oncogene Proteins c-mycRNA, MessengerCancerMycProtein synthesisRibosomeTranslation

Identifiers

PMID34019295
OpenAlexW3161597565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.