Evidence map›Paper›PMID 34019247›Full record

ReviewAdvances in therapy2021

Unmet Clinical Needs in Elderly Patients Receiving Direct Oral Anticoagulants for Stroke Prevention in Non-valvular Atrial Fibrillation.

Gianluca Botto, Pietro Ameri, Manuel Cappellari, Francesco Dentali, Nicola Ferri, Iris Parrini, Italo Porto, Alessandro Squizzato, Giuseppe Camporese

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Gianluca BottoCardiologia Elettrofisiologia, ASST Rhodense, Rho and Garbagnate Hospitals, Milan, Italy.
Pietro AmeriCardiovascular Disease Unit, Department of Internal Medicine, IRCCS Ospedale Policlinico, University of Genova, Genoa, Italy.
Manuel CappellariStroke Unit, Department of Neurosciences, University Hospital of Verona, Verona, Italy.
Francesco DentaliDepartment of Medicine and Surgery, Insubria University, Varese, Italy.
Nicola FerriDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Iris ParriniS.C. Cardiologia, Ospedale Mauriziano Umberto I, Turin, Italy.
Italo PortoClinic of Cardiovascular Diseases, University of Genoa, Genoa, Italy.
Alessandro SquizzatoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Giuseppe CamporeseAngiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padua, Padua, Italy. giuseppe.camporese@aopd.veneto.it.ORCID http://orcid.org/0000-0002-0881-5429
University of Insubria · ITUniversity of Padua · ITAziende Socio Sanitaria Territoriale RhodenseIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Policlinico San Martino · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin K antagonists have been used for many years as the treatment of choice for long-term oral anticoagulation in patients with non-valvular atrial fibrillation. Unfortunately, the use of those drugs in the real-world setting, particularly among elderly patients, is suboptimal because of their limitations in management. Therefore, many patients were not adequately anticoagulated. Direct oral anticoagulants have been demonstrated to overcome almost all the limitations derived from the use of vitamin K antagonists. Direct oral anticoagulants are at least as effective as vitamin K antagonists in preventing thromboembolic events in patients with non-valvular atrial fibrillation and safer in reducing the risk of intracranial haemorrhage and all-cause mortality. However, as a result of the strict inclusion and exclusion criteria applied to patients, data coming from randomized controlled trials might not apply to the general population. Furthermore, elderly patients were scarcely represented in randomized controlled trials with direct oral anticoagulants. Therefore in elderly patients with non-valvular atrial fibrillation, unmet clinical needs still exist. This review article highlights some of them and provides potential answers based on the results coming from randomized clinical trials, real-world data, and the authors' clinical experience.

Indexed as

Atrial FibrillationStrokeThromboembolismAdministration, OralAgedAnticoagulantsHumansRandomized Controlled Trials as TopicAnticoagulantsAtrial fibrillationDirect oral anticoagulantsElderlyUnmet clinical needs

Identifiers

PMID34019247
PMCPMC8189975
OpenAlexW3160248515

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.