Evidence map›Paper›PMID 34019246›Full record

ArticleAdvances in therapy2021

Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Chao Chen, Kui-Fang Du, Lian-Yong Xie, Tai-Yi Jiang, Wen-Jun Kong, Hong-Wei Dong, Chun-Gang Guo, Xiao-Na Li, Wen-Bin Wei

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chao Chen *Department of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Kui-Fang Du *Department of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Lian-Yong XieDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Tai-Yi JiangDepartment of Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Wen-Jun KongDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Hong-Wei DongDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Chun-Gang GuoDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Xiao-Na LiDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
Wen-Bin WeiBeijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China. weiwb1023@163.com.
Capital Medical University · CNBeijing YouAn Hospital · CNBeijing Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

methodsA total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. The patients were divided into four groups according to fundus disease: a normal fundi group, an HIV-related microvascular retinopathy (MVR) group, a cytomegalovirus retinitis (CMVR) group, and a syphilis-related retinopathy group.

resultsThe incidence of fundus disease was 70.7%. There were 36 patients with normal fundi (29.3%), 40 with HIV-related MVR (31.0%), 25 with CMVR (19.4%) (including 11 cases of CMVR with syphilis-related retinopathy), 26 (20.2%) with syphilis-related retinopathy, 1 (0.78%) case with acute retinal necrosis, and 1 (0.78%) case with PORN. The median blood CD4 + T-cell count in the syphilis-associated retinopathy group was 357.5 cells/μl, which was significantly higher than in the other groups; this difference was statistically significant. In the CMVR group, 11 cases with concomitant syphilis-associated retinopathy had lower BCVA and 10 (90.9%) had active inflammatory manifestations in the anterior segment.

conclusionThe incidence of ocular pathology was high in patients co-infected with AIDS and syphilis, which might manifest in a variety of ocular manifestations; some patients may also have multiple ocular changes, which should be given great clinical attention.

Indexed as

Acquired Immunodeficiency SyndromeCytomegalovirus RetinitisRetinal DiseasesSyphilisHumansRetrospective StudiesAcquired immune deficiency syndrome (AIDS)CD4 + T cellCytomegalovirus retinitis (CMV)Optic neuritisRetinal chorioretinitisRetinal microangiopathySyphilis

Identifiers

PMID34019246
OpenAlexW3163518479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.