Evidence map›Paper›PMID 34019237›Full record

ArticleEndocrine pathology2021

Pathogenic ATM Variant-Harbouring Well-Differentiated Aggressive Type 1 Gastric Neuroendocrine Tumour with High-grade Features (G3 NET): a New Addition to the Clinical and Pathological Spectrum of Gastric Neuroendocrine Neoplasms.

Hussein Nassereddine, Matthieu Chicaud, Khedidja Rebah, Nathalie Théou-Anton, Anne Sautet, Jacques Dermer, Anne Couvelard

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In one paragraph

Article in Endocrine pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hussein Nassereddine *Département de Pathologie, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France. hussein.nassereddine@hotmail.com.ORCID http://orcid.org/0000-0003-0488-2402
Matthieu Chicaud *Département de Pathologie, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.
Khedidja RebahDépartement de Génétique, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.
Nathalie Théou-AntonDépartement de Génétique, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.
Anne SautetPRAXEA Diagnostics, Massy, France.
Jacques DermerService de Chirurgie Viscérale Et Cancérologique, Clinique de L'Estrée, 93245, Stains, France.
Anne CouvelardDépartement de Pathologie, Hôpital Bichat, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric type 1 neuroendocrine tumours are considered to have low rates of proliferation and a good prognosis. We report here a patient with an aggressive well-differentiated high-grade gastric neuroendocrine tumour (gastric grade 3 NET), in a context of autoimmune gastritis. Consistent with grade 3 disease, the tumour had a Ki-67 proliferation index of 30%. Targeted next-generation sequencing identified variants of four genes, including a pathogenic ATM variant underlying the differentiation and metastatic potential of the tumour. Liver metastasis was diagnosed during follow-up, and the patient died after 6 years, due to disease progression.

Indexed as

AgedAtaxia Telangiectasia Mutated ProteinsCell DifferentiationDiagnosis, DifferentialFatal OutcomeFemaleFranceHumansLiver NeoplasmsNeoplasm GradingNeoplasm InvasivenessNeuroendocrine TumorsStomach NeoplasmsAtaxia Telangiectasia Mutated ProteinsATM protein, humanAutoimmune gastritisGastricGrade 3Neuroendocrine tumourType 1

Identifiers

PMID34019237
OpenAlexW3162884545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.