Evidence map›Paper›PMID 34019227›Full record

ArticleJapanese journal of radiology2021

Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer's disease.

Tanyaluck Thientunyakit, Thonnapong Thongpraparn, Chakmeedaj Sethanandha, Takahiro Yamada, Yuichi Kimura, Weerasak Muangpaisan, Kazunari Ishii

Abstract read
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In one paragraph

Article in Japanese journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tanyaluck ThientunyakitDepartment of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand. stanyalu@hotmail.com.ORCID http://orcid.org/0000-0002-6139-7887
Thonnapong ThongpraparnDepartment of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.
Chakmeedaj SethanandhaDepartment of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.
Takahiro YamadaInstitute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Yuichi KimuraGraduate School of Biology-Oriented Science and Technology, Kindai University, 930 Nishimitani, Kinokawa City, Wakayama, 649-6493, Japan.
Weerasak MuangpaisanDepartment of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.
Kazunari IshiiInstitute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Siriraj Hospital · THKindai University Hospital · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer's disease (AD). MATERIALS AND

methodsFifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT scans were divided into four groups (A, normal; B, MCI; C, mild AD; and D, moderate/severe AD). Semiquantitative analyses of SUVR images were performed. The differences between groups and the correlations between florbetapir uptake and Thai Mental State Examination (TMSE) scores were determined. Significant differences were defined using a P < 0.001, uncorrected, or a P < 0.05, FWE for the voxel-based analyses with Statistical Parametric Mapping (SPM).

resultsThere was a slightly higher florbetapir uptake in the precuneus, parietal, and occipital association cortices in Group B > A. The occipital florbetapir uptake in Groups C and D was significantly higher than in Group A, in addition to the precuneus, anterior cingulate, posterior cingulate, temporoparietal, and frontal cortices. There was a strong negative correlation between TMSE scores and florbetapir uptake in the occipital lobe.

conclusionsOccipital amyloid uptake is associated with clinically advanced AD, and is inversely correlated with neurocognitive performance and may be useful for evaluating AD severity.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAniline CompoundsEthylene GlycolsHumansOccipital LobePositron-Emission TomographyPositron Emission Tomography Computed TomographyAniline CompoundsEthylene GlycolsflorbetapirAlzheimer’s diseaseAmyloid PETFlorbetapirOccipital

Identifiers

PMID34019227
OpenAlexW3160290818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.