Evidence map›Paper›PMID 34018932›Full record

ArticleIEEE transactions on medical imaging2021

Automatic Inter-Frame Patient Motion Correction for Dynamic Cardiac PET Using Deep Learning.

Luyao Shi, Yihuan Lu, Nicha Dvornek, Christopher A Weyman, Edward J Miller, Albert J Sinusas, Chi Liu

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Applications of artificial intelligence in nuclear medicine.Zeitschrift fur medizinische Physik · 2026
    Review
  4. Article
  5. Dynamic frame-by-frame motion correction forEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Article
  7. A deep learning method for total-body dynamic PET imaging with dual-time-window protocols.European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Detection and correction of patient motion in dynamicJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  14. TAI-GAN: Temporally and Anatomically Informed GAN for Early-to-Late Frame Conversion in Dynamic Cardiac PET Motion Correction.Simulation and synthesis in medical imaging : ... International Workshop, SASHIMI ..., held in conjunction with MICCAI ..., proceedings. SASHIMI (Workshop) · 2023
    Article
  15. Article
  16. Article
  17. MCP-Net: Inter-frame Motion Correction with Patlak Regularization for Whole-body Dynamic PET.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luyao Shi
Yihuan Lu
Nicha Dvornek
Christopher A Weyman
Edward J Miller
Albert J Sinusas
Chi Liu

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development of advanced cardiac SPECT imaging technologiesR01HL154345 · NHLBI · YALE UNIVERSITY · PI LIU, CHI, SINUSAS, ALBERT J · 2020 to 2023
$3.2M
Quantitative Low-Dose PET ImagingR01EB025468 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LIU, CHI · 2018 to 2022
$3.2M
Personalized Task-Based Respiratory Motion Correction for Low-Dose PET/CTR01CA224140 · NCI · YALE UNIVERSITY · PI LIU, CHI, SPOTTISWOODE, BRUCE SHAWN · 2018 to 2022
$3.1M
Data-Driven Simultaneous Respiratory and Body Motion Correction for PET/CTR03EB027209 · NIBIB · YALE UNIVERSITY · PI LU, YIHUAN · 2019 to 2020
$168k
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA224140NHLBI NIH HHS R01 HL154345NIBIB NIH HHS R01 EB025468NIBIB NIH HHS R03 EB027209
6 · The paper itself

Abstract

Patient motion during dynamic PET imaging can induce errors in myocardial blood flow (MBF) estimation. Motion correction for dynamic cardiac PET is challenging because the rapid tracer kinetics of 82Rb leads to substantial tracer distribution change across different dynamic frames over time, which can cause difficulties for image registration-based motion correction, particularly for early dynamic frames. In this paper, we developed an automatic deep learning-based motion correction (DeepMC) method for dynamic cardiac PET. In this study we focused on the detection and correction of inter-frame rigid translational motion caused by voluntary body movement and pattern change of respiratory motion. A bidirectional-3D LSTM network was developed to fully utilize both local and nonlocal temporal information in the 4D dynamic image data for motion detection. The network was trained and evaluated over motion-free patient scans with simulated motion so that the motion ground-truths are available, where one million samples based on 65 patient scans were used in training, and 600 samples based on 20 patient scans were used in evaluation. The proposed method was also evaluated using additional 10 patient datasets with real motion. We demonstrated that the proposed DeepMC obtained superior performance compared to conventional registration-based methods and other convolutional neural networks (CNN), in terms of motion estimation and MBF quantification accuracy. Once trained, DeepMC is much faster than the registration-based methods and can be easily integrated into the clinical workflow. In the future work, additional investigation is needed to evaluate this approach in a clinical context with realistic patient motion.

Indexed as

Deep LearningHumansImage Processing, Computer-AssistedMotionMovementPositron-Emission Tomography

Identifiers

PMID34018932
PMCPMC8670362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.