Evidence map›Paper›PMID 34018851›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis.

Adrienne R Guarnieri, Sarah R Anthony, Anamarie Gozdiff, Lisa C Green, Salma M Fleifil, Sam Slone, Michelle L Nieman, Perwez Alam, Joshua B Benoit, A Phillip Owens and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. HuR inhibition reduces post-ischemic cardiac remodeling by dampening myocyte-dependent inflammatory gene expression and the innate immune response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Review
  6. UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  7. RNA binding proteins as mediators of pathological cardiac remodeling.Frontiers in cell and developmental biology · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Extracellular vesicle-mediated bidirectional communication between heart and other organs.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  13. Article
  14. HuR brings the heat: linking adipose tissue to cardiac dysfunction.American journal of physiology. Heart and circulatory physiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Adrienne R GuarnieriDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Sarah R AnthonyDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Anamarie GozdiffDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lisa C GreenDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-1164-6611
Salma M FleifilDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Sam SloneDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Michelle L NiemanDepartment of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Perwez AlamDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio.
A Phillip OwensDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Onur KanisicakDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-8393-4874
Michael TranterDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
University of Cincinnati Medical Center · USUniversity of Cincinnati · US

Funding

Understanding Cardiovascular Disease MechanismsT32HL125204 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Evangelia G Kranias, Jeffery D Molkentin · 2015 to 2026
$3.4M
Regulators of extracellular matrix production during cardiac development and diseaseR01HL148598 · NHLBI · UNIVERSITY OF CINCINNATI · PI KANISICAK, ONUR · 2020 to 2024
$2.0M
Investigation of Human Antigen R (HuR) as a Novel Mediator of Cardiac HypertrophyR01HL132111 · NHLBI · UNIVERSITY OF CINCINNATI · PI TRANTER, MICHAEL · 2016 to 2020
$1.8M
NHLBI NIH HHS R01 HL132111NHLBI NIH HHS R01 HL148598NHLBI NIH HHS T32 HL125204
6 · The paper itself

Abstract

Adipose tissue homeostasis plays a central role in cardiovascular physiology, and the presence of thermogenically active brown adipose tissue (BAT) has recently been associated with cardiometabolic health. We have previously shown that adipose tissue-specific deletion of HuR (Adipo-HuR

Indexed as

AdipocytesAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsCardiomegalyELAV-Like Protein 1FibrosisMiceMice, KnockoutMyocardiumELAV-Like Protein 1adipose tissuecardiac hypertrophycardiovascular diseasefibrosisHuR

Identifiers

PMID34018851
PMCPMC8321812
OpenAlexW3162857360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.