Evidence map›Paper›PMID 34018825›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Early stopping in clinical PET studies: How to reduce expense and exposure.

Jonas E Svensson, Martin Schain, Gitte M Knudsen, R Todd Ogden, Pontus Plavén-Sigray

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonas E SvenssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2331-4913
Martin SchainNeurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.
Gitte M KnudsenNeurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.
R Todd OgdenDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Pontus Plavén-SigrayCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5342-5641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply

Indexed as

AdultBayes TheoremCase-Control StudiesComputer SimulationEarly Termination of Clinical TrialsFemaleHumansMaleMiddle AgedPositron-Emission TomographyRadiation ExposureResearch DesignSample SizeBayes factorEarly stoppingpositron emission tomographysequential testingtutorial

Identifiers

PMID34018825
PMCPMC8545054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.