Evidence map›Paper›PMID 34018686›Full record

ArticleChemMedChem2021

Platinum Cyclooctadiene Complexes with Activity against Gram-positive Bacteria.

Angelo Frei, Soumya Ramu, Gabrielle J Lowe, Hue Dinh, Lucie Semenec, Alysha G Elliott, Johannes Zuegg, Anke Deckers, Nicole Jung, Stefan Bräse and 2 more

Abstract read
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Biological Evaluation of Dinuclear Platinum(II) Complexes with AromaticInternational journal of molecular sciences · 2024
    Review
  8. The Antimicrobial Properties of PdChembiochem : a European journal of chemical biology · 2023
    Article
  9. Article
  10. Article
  11. Half-Sandwich Type Platinum-Group Metal Complexes ofMolecules (Basel, Switzerland) · 2023
    Article
  12. Review
  13. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Angelo FreiCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-6169-2491
Soumya RamuCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Gabrielle J LoweCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Hue DinhARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Lucie SemenecARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Alysha G ElliottCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Johannes ZueggCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Anke DeckersInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Nicole JungInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Amy K CainARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Mark A T BlaskovichCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

Funding

Australian Research Council (ARC) DECRA fellowship DE180100929DFG-core facility Molecule Archive 284178167Swiss National Science Foundation P2ZHP2_177997Wellcome TrustWellcome Trust Strategic Grant WT1104797/Z/14/Z
6 · The paper itself

Abstract

Antimicrobial resistance is a looming health crisis, and it is becoming increasingly clear that organic chemistry alone is not sufficient to continue to provide the world with novel and effective antibiotics. Recently there has been an increased number of reports describing promising antimicrobial properties of metal-containing compounds. Platinum complexes are well known in the field of inorganic medicinal chemistry for their tremendous success as anticancer agents. Here we report on the promising antibacterial properties of platinum cyclooctadiene (COD) complexes. Amongst the 15 compounds studied, the simplest compounds Pt(COD)X

Indexed as

AlkadienesAnimalsCoordination ComplexesDose-Response Relationship, DrugGram-Positive BacteriaMicrobial Sensitivity TestsMolecular StructureMothsPlatinumStructure-Activity Relationship1,5-cyclooctadieneAlkadienesCoordination ComplexesPlatinumantibioticinorganic medicinal chemistrymetalloantibioticmetals in medicineplatinum

Identifiers

PMID34018686
PMCPMC8596843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.