ArticleMolecular systems biology2021
Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed.
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- Protein structure-informed bacteriophage genome annotation with Phold.Nucleic acids research · 2026Article
- Differentiating commensal and disease-associatedFrontiers in veterinary science · 2026Article
- Description and evolution of aFrontiers in microbiology · 2026Article
- How and when organisms edit their own genomes.Nature genetics · 2025Review
- Isolation and genomic characterization of Psychrobacillus isolate L3 and bacteriophage Spoks: a new phage-host pair from Antarctic soil.BMC genomics · 2025Article
- Distinct horizontal gene transfer potential of extracellular vesicles versus viral-like particles in marine habitats.Nature communications · 2025Article
- Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements.Nucleic acids research · 2024Article
- Article
- Systematic identification of cargo-mobilizing genetic elements reveals new dimensions of eukaryotic diversity.Nucleic acids research · 2024Article
- The evolution of antibiotic resistance islands occurs within the framework of plasmid lineages.Nature communications · 2024Article
- Bacteriophage lambda site-specific recombination.Molecular microbiology · 2024Review
- Large language models improve annotation of prokaryotic viral proteins.Nature microbiology · 2024Article
- Integrase-associated niche differentiation of endogenous large DNA viruses in crustaceans.Microbiology spectrum · 2024Article
- Geographical distribution of mobile genetic elements in microbial communities along the Yucatan coast.PloS one · 2024Article
- An integrated in-silico approach for drug target identification in human pathogen Shigella dysenteriae.PloS one · 2024Article
- Complete genomes ofMicrobial genomics · 2024Article
- Annotation and Comparative Genomics of Prokaryotic Transposable Elements.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Genomic analysis of hyperparasitic viruses associated with entomopoxviruses.Virus evolution · 2024Article
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3 authors.
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Abstract
Mobile genetic elements (MGEs) sequester and mobilize antibiotic resistance genes across bacterial genomes. Efficient and reliable identification of such elements is necessary to follow resistance spreading. However, automated tools for MGE identification are missing. Tyrosine recombinase (YR) proteins drive MGE mobilization and could provide markers for MGE detection, but they constitute a diverse family also involved in housekeeping functions. Here, we conducted a comprehensive survey of YRs from bacterial, archaeal, and phage genomes and developed a sequence-based classification system that dissects the characteristics of MGE-borne YRs. We revealed that MGE-related YRs evolved from non-mobile YRs by acquisition of a regulatory arm-binding domain that is essential for their mobility function. Based on these results, we further identified numerous unknown MGEs. This work provides a resource for comparative analysis and functional annotation of YRs and aids the development of computational tools for MGE annotation. Additionally, we reveal how YRs adapted to drive gene transfer across species and provide a tool to better characterize antibiotic resistance dissemination.
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