Evidence map›Paper›PMID 34018297›Full record

ReviewAngewandte Chemie (International ed. in English)2021

Enabling Clinical Technologies for Hyperpolarized

Alixander S Khan, Rebecca L Harvey, Jonathan R Birchall, Robert K Irwin, Panayiotis Nikolaou, Geoffry Schrank, Kiarash Emami, Andrew Dummer, Michael J Barlow, Boyd M Goodson and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Alixander S KhanSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
Rebecca L HarveySir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
Jonathan R BirchallIntergrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), 5101 Cass Avenue, Detroit, MI, 48202, USA.ORCID 0000-0003-3920-4038
Robert K IrwinSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
Panayiotis NikolaouXeUS Technologies, Nicosia, 2312, Cyprus.ORCID 0000-0002-3802-0803
Geoffry SchrankNorthrup Grumman Space Systems, 45101 Warp Drive, Sterling, VA, 20166, USA.
Kiarash EmamiPolarean Inc., Durham, NC, 27713, USA.
Andrew DummerPolarean Inc., Durham, NC, 27713, USA.ORCID 0000-0001-9762-6533
Michael J BarlowSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
Boyd M GoodsonDepartment of Chemistry and Biochemistry, Southern Illinois University, 1245 Lincoln Drive, Carbondale, IL, 62901, USA.ORCID 0000-0001-6079-5077
Eduard Y ChekmenevIntergrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), 5101 Cass Avenue, Detroit, MI, 48202, USA.ORCID 0000-0002-8745-8801
University of Nottingham · GBResearch Square (United States) · USNorthrop Grumman (United States) · USRussian Academy of Sciences · RUSouthern Illinois University Carbondale · USWayne State University · USXeUS Technologies (Cyprus) · CY

Funding

A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRIR21HL154032 · NHLBI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2020 to 2021
$419k
Congressionally Directed Medical Research Programs W81XWH-12-1-0159/BC112431Congressionally Directed Medical Research Programs W81XWH-15-1-0271Congressionally Directed Medical Research Programs W81XWH-15-1-0272Congressionally Directed Medical Research Programs W81XWH-20-10576Congressionally Directed Medical Research Programs W81XWH-20-10578Division of Chemistry CHE-1904780Division of Chemistry CHE-1905341James Tudor Foundation and EPSRC-IAANHLBI NIH HHS 5R44HL123299-04NHLBI NIH HHS R21 HL154032NHLBI NIH HHS R21HL154032NHLBI NIH HHS R44 HL123299Research Corporation for Science Advancement Cottrell SEED AwardSchool of Medicine, University of Nottingham
6 · The paper itself

Abstract

Hyperpolarization is a technique that can increase nuclear spin polarization with the corresponding gains in nuclear magnetic resonance (NMR) signals by 4-8 orders of magnitude. When this process is applied to biologically relevant samples, the hyperpolarized molecules can be used as exogenous magnetic resonance imaging (MRI) contrast agents. A technique called spin-exchange optical pumping (SEOP) can be applied to hyperpolarize noble gases such as

Indexed as

HumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyXenonXenon129Xehyperpolarizationmagnetic resonance imagingNMR spectroscopyspin-exchange optical pumping

Identifiers

PMID34018297
PMCPMC8478785
OpenAlexW3163902979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.