Evidence map›Paper›PMID 34018096›Full record

Trial reportJournal of cancer survivorship : research and practice2022

The impact of weight loss on physical function and symptoms in overweight or obese breast cancer survivors: results from POWER-remote.

Jennifer Y Sheng, Cesar A Santa-Maria, Amanda L Blackford, David Lim, Ashley Carpenter, Karen L Smith, Gary I Cohen, Janelle Coughlin, Lawrence J Appel, Vered Stearns and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Social-cognitive, demographic, clinical, and health-related correlates of physical activity and sedentary behaviour in newly diagnosed women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jennifer Y ShengDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. jsheng7@jhmi.edu.ORCID 0000-0002-4513-4235
Cesar A Santa-MariaDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Amanda L BlackfordDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
David LimDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ashley CarpenterDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Karen L SmithDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gary I CohenGreat Baltimore Medical Center, Baltimore, MD, USA.
Janelle CoughlinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence J AppelDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vered StearnsDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Claire SnyderDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USGreater Baltimore Medical Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

purposeIn pre-planned observational analysis of the POWER-remote trial, we examined the impact of weight loss on patient-reported outcomes (PROs). We hypothesized a priori that survivors with ≥ 5% weight loss would have improved physical function (PF) at 6 months vs. those who did not.

methodsPatients with stage 0-III breast cancer who completed local therapy and chemotherapy with BMI ≥ 25 kg/m

resultsOf 94 women who completed PROs, 84 and 69 participants were evaluable at 6 and 12 months, respectively. Regardless of intervention, PF improved in those with ≥ 5% weight loss vs. those with < 5% at 6 months (4.4 vs. 0.3 points; p = 0.02) and 12 months (3.6 vs. 0 points; p = 0.04). While endocrine symptoms, fatigue, and anxiety improved at 6 months in those who lost ≥ 5%, differences were not significant vs. those who lost < 5%. There was no significant change within or between groups in sexual function, depression, or sleep. Findings at 12 months were similar, except pain improved in those losing ≥ 5%.

conclusionsThese results support the benefits of weight loss in overweight/obese breast cancer survivors. IMPLICATIONS FOR CANCER SURVIVORS: Weight management in breast cancer survivors may improve PF.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseFatigueFemaleHumansObesityOverweightPainSurvivorsWeight LossBreast cancerObesityPatient reported outcomesPhysical function

Identifiers

PMID34018096
PMCPMC8605026
OpenAlexW3163933511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.