Evidence map›Paper›PMID 34018083›Full record

ArticleAnnals of surgical oncology2021

Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.

Daniel R Evans, Alexander L Lazarides, Mark M Cullen, Julia D Visgauss, Jason A Somarelli, Dan G Blazer, Brian E Brigman, William C Eward

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Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Elevated risk of wound and systemic complications in MRSA-colonized patients undergoing lower extremity orthopedic trauma surgery.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel R Evans *Duke University School of Medicine, Durham, NC, USA.
Alexander L Lazarides *Department of Orthopaedic Surgery, Duke University Hospital, Durham, NC, USA. Alexander.lazarides@duke.edu.ORCID http://orcid.org/0000-0003-0704-1529
Mark M CullenDuke University School of Medicine, Durham, NC, USA.
Julia D VisgaussDepartment of Orthopaedic Surgery, Duke University Hospital, Durham, NC, USA.
Jason A SomarelliDuke Cancer Institute, Duke University Hospital, Durham, NC, USA.
Dan G BlazerDuke Cancer Institute, Duke University Hospital, Durham, NC, USA.
Brian E BrigmanDepartment of Orthopaedic Surgery, Duke University Hospital, Durham, NC, USA.
William C EwardDepartment of Orthopaedic Surgery, Duke University Hospital, Durham, NC, USA.
Duke University Hospital · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data to inform risk of readmission and short-term mortality in musculoskeletal oncology. The goal of this study was to identify factors independently associated with 30-day readmission and 90-day mortality following surgical resection of osteosarcoma.

methodsWe retrospectively reviewed patients (n = 5293) following surgical resection of primary osteosarcoma in the National Cancer Database (2004-2015). Univariate and multivariate methods were used to correlate variables with readmission and short-term mortality.

resultsOf 210 readmissions (3.97%), risk factors independently associated with unplanned 30-day readmission included comorbidity burden (odds ratio [OR] 2.4, p = 0.042), Medicare insurance (OR 1.9, p = 0.021), and axial skeleton location (OR 1.5, p = 0.029). A total of 91 patients died within 90 days of their surgery (1.84%). Risk factors independently associated with mortality included age (hazard ratio 1.1, p < 0.001), increasing comorbidity burden (OR 6.6, p = 0.001), higher grade (OR 1.7, p = 0.007), increasing tumor size (OR 2.2, p = 0.03), metastatic disease at presentation (OR 8.5, p < 0.001), and amputation (OR 2.0, p = 0.04). Chemotherapy was associated with a decreased risk of short-term mortality (p < 0.001).

conclusionsSeveral trends were clear: insurance status, tumor location and comorbidity burden were independently associated with readmission rates, while age, amputation, grade, tumor size, metastatic disease, and comorbidity burden were independently associated with short-term mortality.

Indexed as

Bone NeoplasmsOsteosarcomaAgedComorbidityDatabases, FactualHumansMedicarePatient ReadmissionPostoperative ComplicationsRetrospective StudiesRisk FactorsUnited States

Identifiers

PMID34018083
OpenAlexW3163737739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.