ReviewJournal of experimental botany2021
Single-cell analysis of cell identity in the Arabidopsis root apical meristem: insights and opportunities.
Review in Journal of experimental botany, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Single-cell RNA-sequencing profiles reveal the developmental landscape of hawthorn leaves.BMC plant biology · 2026Article
- Integrated single cell transcriptomics analysis for unraveling heterogeneity and plasticity of root cells for sustainable and regenerative agriculture.Frontiers in plant science · 2026Review
- Single-cell transcriptome atlas unveils transcriptional regulation networks of banana root tips in response toHorticulture research · 2025Article
- Single-cell transcriptome sequencing reveals the sphingolipid metabolism pathway plays an important role in leaf senescence in tobacco.BMC plant biology · 2025Article
- Single-cell omics in plant biology: mechanistic insights and applications for crop improvement.Advanced biotechnology · 2025Review
- Post-translational modification acts as a digital like switch influencing AtPIP2;1 water and cation permeability.Scientific reports · 2025Article
- A space for time. Exploring temporal regulation of plant development across spatial scales.The Plant journal : for cell and molecular biology · 2025Review
- MicroRNA control of stem cell reconstitution and growth in root regeneration.Nature plants · 2025Article
- Single-nucleus RNA and ATAC sequencing analyses provide molecular insights into early pod development of peanut fruit.Plant communications · 2024Article
- A single-cell transcriptome atlas reveals the trajectory of early cell fate transition during callus induction in Arabidopsis.Plant communications · 2024Article
- Harnessing the Genetic Basis of Sorghum Biomass-Related Traits to Facilitate Bioenergy Applications.International journal of molecular sciences · 2023Article
- Article
- microRNA165 and 166 modulate response of the Arabidopsis root apical meristem to salt stress.Communications biology · 2023Article
- Reference genes for quantitative Arabidopsis single molecule RNA fluorescence in situ hybridization.Journal of experimental botany · 2023Article
- Brassinosteroid gene regulatory networks at cellular resolution in theScience (New York, N.Y.) · 2023Article
- A blast from the past: Understanding stem cell specification in plant roots using laser ablation.Quantitative plant biology · 2023Article
- Development specifies, diversifies and empowers root immunity.EMBO reports · 2022Review
- scCloudMine: A cloud-based app for visualization, comparison, and exploration of single-cell transcriptomic data.Plant communications · 2022Article
- Single-Cell RNA Sequencing for Plant Research: Insights and Possible Benefits.International journal of molecular sciences · 2022Review
- Unleashing the power within short-read RNA-seq for plant research: Beyond differential expression analysis and toward regulomics.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A fundamental question in developmental biology is how the progeny of stem cells become differentiated tissues. The Arabidopsis root is a tractable model to address this question due to its simple organization and defined cell lineages. In particular, the zone of dividing cells at the root tip-the root apical meristem-presents an opportunity to map the gene regulatory networks underlying stem cell niche maintenance, tissue patterning, and cell identity acquisition. To identify molecular regulators of these processes, studies over the last 20 years employed global profiling of gene expression patterns. However, these technologies are prone to information loss due to averaging gene expression signatures over multiple cell types and/or developmental stages. Recently developed high-throughput methods to profile gene expression at single-cell resolution have been successfully applied to plants. Here, we review insights from the first published single-cell mRNA sequencing and chromatin accessibility datasets generated from Arabidopsis roots. These studies successfully reconstruct developmental trajectories, phenotype cell identity mutants at unprecedented resolution, and reveal cell type-specific responses to environmental stimuli. The experimental insight gained from Arabidopsis paves the way to profile roots from additional species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.