Evidence map›Paper›PMID 34017941›Full record

ArticlemicroPublication biology2021

Recombination and biased segregation of mitochondrial genomes during crossing and meiosis of different

Stephan Kamrad, María Rodríguez-López, Shoumit Dey, Mimoza Hoti, Henry Wallace, Markus Ralser, Jürg Bähler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephan KamradUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
María Rodríguez-LópezUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
Shoumit DeyUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
Mimoza HotiUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
Henry WallaceUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
Markus RalserThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, U.K.
Jürg BählerUniversity College London, Institute of Healthy Ageing and Department of Genetics, Evolution & Environment, London, U.K.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

Wellcome Trust FC001134
6 · The paper itself

Abstract

During meiosis, tethering of parental mitochondria to opposite cell poles inhibits the mixing of mitochondria with different genomes and ensures uniparental inheritance in thestandard laboratory strain of fission yeast. We here investigate mitochondrial inheritance in crosses between natural isolates using tetrad dissection and next-generation sequencing. We find that colonies grown from single spores can sometimes carry a mix of mitochondrial genotypes, that mitochondrial genomes can recombine during meiosis, that in some cases tetrads do not follow the 2:2 segregation pattern, and that certain crosses may feature a weak bias towards one of the parents. Together, these findings paint a more nuanced picture of mitochondrial inheritance in the wild.

Identifiers

PMID34017941
PMCPMC8129777
OpenAlexW3162874553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.