Evidence map›Paper›PMID 34017587›Full record

ArticleRare tumors2021

Nature and significance of stromal differentiation in carcinosarcoma (MMMT): unravelling the biology and shifting current paradigms.

Sean Hacking, Dongling Wu, Rafae Nasim, Hector Chavarria, Mansoor Nasim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rare tumors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sean HackingDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, New York, NY, USA.ORCID https://orcid.org/0000-0001-6061-0781
Dongling WuDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, New York, NY, USA.
Rafae NasimAlbany Medical College, Albany, NY, USA.
Hector ChavarriaDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, New York, NY, USA.
Mansoor NasimDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinosarcoma (CS) is a rare, aggressive malignancy of the Mullerian system often termed mixed malignant Mullerian tumor (MMMT). It is biphasic in nature, differentiating into epithelial and sarcomatous components. Tumor-node-metastasis (TNM) staging and mismatch repair (MMR) status is the basis for both prognostication and therapeutic decision making. However, stromal differentiation (SD) is a new frontier in the field of histopathology and many studies have demonstrated its prognostic significance. The present study is the first study to evaluate the role of SD in carcinosarcoma. Here we found immature SD to be a significant prognostic signature (

Indexed as

Carcinosarcomaclinical practiceprognosisstromal differentiation

Identifiers

PMID34017587
PMCPMC8114287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.