ArticleAmerican journal of translational research2021
The changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and analysis of their correlation with inflammatory factors and prognosis.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.Cell biochemistry and biophysics · 2025Article
- Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention-A cross-sectional study.Nursing open · 2023Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
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Abstract
objectiveTo explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis.
methodsA total of 122 subjects with coronary heart disease who underwent interventional therapy in our hospital from January 2017 to January 2019 were chosen as the observation group, and 122 healthy people during the same period were chosen as the control group. We retrospectively analyzed the levels of serum miR-221, miR-222, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Pearson correlation analysis was used to reveal the relationship between serum levels of miR-221, miR-222 and CRP, TNF-α and IL-6, N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction (LVEF%) in the observation group. The levels of serum miR-221, miR-222, TNF-α, CRP and IL-6 before and after treatment were compared in the observation group. After a follow-up of 6 months, the observation group was divided into a poor-prognosis group (26 cases) and a good-prognosis group (96 cases) according to whether there was an adverse cardiovascular event or not. The levels of serum miR-221 and miR-222 before and after intervention treatment were compared between the two groups. And the clinical values of miR-221 and miR-222 levels before and after intervention treatment in the observation group were analyzed by the ROC curve.
resultsThe levels of serum miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were markedly higher than those of the control group. And levels of serum miR-221, miR-222 were negatively correlated with LVEF% while positively correlated with CRP, TNF-α, IL-6 and NT-proBNP (P<0.05). After treatment, the levels of miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were significantly reduced (all P<0.05). Compared with the good prognosis group, the levels of miR-221 and miR-222 before and after treatment were markedly higher in the poor prognosis group (all P<0.05). Both before and after treatment, the levels of miR-221 and miR-222 have certain clinical value in evaluating the prognosis (all AUC>0.800).
conclusionThe levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. The levels of miR-221 and miR-222 before and after treatment have certain clinical value in evaluating the prognosis of patients.
Indexed as
Identifiers
34017558PMC8129388W3162605136What OpenQuestion holds
Registered trials
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