ArticleAmerican journal of translational research2021
Effect of pulmonary surfactant on the prevention of neonatal respiratory distress syndrome in premature infants.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
- A systematic scoping review of the use of surfactant replacement therapy for respiratory distress syndrome in preterm neonates in low- and middle-income countries.Frontiers in pediatrics · 2025Pooled it
- Article
- A nationwide survey on the management of neonatal respiratory distress syndrome: insights from the MUNICH survey in 394 Chinese hospitals.Italian journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of pulmonary surfactant on the prevention of neonatal respiratory distress syndrome (NRDS) in premature infants.
methodsA total of 216 premature infants in our hospital were selected. According to the guardian's choice, premature infants were grouped into treatment with pulmonary surfactant (PS) combined with nasal continuous positive airway pressure (NCPAP; the observation group) and treatment with NCPAP alone (the control group). The observation group was further divided into the young gestational age group (group A, 40 cases) and old gestational age group (group B, 74 cases), while the control group was divided into the young gestational age group (group C, 35 cases) and old gestational age group (group D, 67 cases). The incidence of NRDS, the first and second use of PS, the number of cases with mechanical ventilation, use of oxygen time, length of hospital stay and complications were observed.
resultsThe incidence of NRDS in the observation group was lower than that in the control group, but the first use rate of PS was higher than in the control group (P<0.05). The incidence of NRDS in group A was lower than that in the other three groups (P<0.001), while the mechanical ventilation rate in group C was higher than that in the other three groups (P<0.001). Use of oxygen time and length of hospital stay in groups A and C were higher than those in groups B and D (P<0.001). The mortality rate of group A was lower than that of group C (P<0.05). There was no difference in complications among patients with different gestational ages (P>0.05).
conclusionEarly use of PS can prevent the incidence of NRDS in preterm infants, significantly reduce the incidence of NRDS in neonates with young gestational age. It can also improve the survival rate of patients with young gestational age without increasing the incidence of complications.
Indexed as
Identifiers
34017546PMC8129273W3160487058What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.