Evidence map›Paper›PMID 34017536›Full record

ArticleAmerican journal of translational research2021

Malat-1 expression in bladder carcinoma tissues and its clinical significance.

Tiejun Liang, Faren Xu, Peng Wan, Li Zhang, Shaojun Huang, Nannan Yang, Yueyue Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tiejun LiangDepartment of Urology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Faren XuDepartment of Urology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Peng WanDepartment of Urology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Li ZhangDepartment of Pathology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Shaojun HuangDepartment of Urology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Nannan YangDepartment of Urology, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Yueyue WangVIP Ward, The People's Hospital of Xinchang Xinchang, Zhejiang Province, China.
Xintai People's Hospital · CNZhejiang Medicine (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression of metastasis-associated lung adenocarcinoma transcript 1 (Malat-1) in bladder carcinoma and its relationship with clinicopathological characteristics and prognosis.

methodsSpecimens were collected from 90 patients with bladder carcinoma who underwent urological surgery in our hospital. Twenty patients diagnosed with benign prostatic hyperplasia were selected as the negative control. The expression of Malat-1 was detected by real-time reverse transcription PCR, and its relationship with clinicopathological factors and prognosis was analyzed.

resultsThe expression of Malat-1 in bladder carcinoma tissues (2.55±0.31) was higher than that in adjacent tissues (1.62±0.42) and normal bladder mucosa tissues (0.84±0.06); the differences were statistically significant (t=13.647 and 27.302, both P<0.001). The high expression rate of Malat-1 in bladder carcinoma tissues (86.67%) was significantly higher than that in adjacent tissues (22.22%) and normal bladder mucosa tissues (5.00%; P=0.000 and 0.000). The high expression rate of Malat-1 was correlated with age, tumor staging, degree of differentiation and lymph node metastasis (P=0.018, 0.000, 0.000, and 0.000). The median survival time and the 1-year, 3-year and 5-year survival rates of patients with high Malat-1 expression were lower than those with low expression of Malat-1 (P=0.006, 0.011, 0.000 and 0.002). High expression of Malat-1 is an independent risk factor for poor overall survival (OS) in bladder cancer patients.

conclusionOverexpression of Malat-1 in bladder carcinoma tissues is associated with malignant biological characteristics and poor prognosis of patients.

Indexed as

bladder carcinomainvasionMetastasis-associated lung adenocarcinoma transcript 1prognosis

Identifiers

PMID34017536
PMCPMC8129343
OpenAlexW3160243615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.