Clinical study of abnormal glucose metabolism and insulin resistance in patients with liver cirrhosis.

backgroundTo investigate the correlation between abnormal glucose metabolism and insulin resistance in patients with liver cirrhosis.

methodsA total of 254 participants were assigned into either the experimental group (EG) (n=123) or the normal group (NG) (n=131). We detected fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting insulin (FINS), postprandial insulin, Hemoglobin A1c (HbA1c) and Insulin sensitivity index (ISI), at the same time, we compared various indexes in different Child-Pugh classification of the experimental group.

resultsThe 1-hour PBG and 2-hour PBG in the EG were significantly higher than the NG group (P<0.05), serum insulin level in each period was significantly higher (P<0.05). The insulin sensitivity index (ISI) in the experimental group was statistical significantly lower (-4.21±0.09) VS. (-4.03±0.32), (P=0.031<0.05). Furthermore, the 2-hour PBG and FIN of Child-Pugh grade B patients were significantly higher than that of Child-Pugh grade A patients. The fasting insulin level of patients with cirrhosis of Child-Pugh grade C patients was significantly higher than that of Child-Pugh grade B patients, while FBG, PBG and ISI had no significant difference compared with those of Child-Pugh grade B patients. The higher the level of fasting blood glucose and postprandial blood glucose, the higher the FIN with the aggravation of liver function damage.

conclusionsPatients with liver cirrhosis had different degrees of insulin resistance. Clinicians can take proactive measures to prevent the occurrence of hepatogenic diabetes mellitus.