ArticleAmerican journal of translational research2021
Treatment efficacy of arterial urokinase thrombolysis combined with mechanical thrombectomy for acute cerebral infarction and its influence on neuroprotective factors and factors for neurological injury.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Plasma hydrogen sulfide as a promising predictor of collateral cerebral circulation in acute ischemic stroke.American journal of translational research · 2025Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to explore the treatment efficacy of arterial urokinase thrombolysis combined with Solitaire AB stent for acute cerebral infarction (ACI) and its influence on neuroprotective factors and factors for neurological injury.
methodsWe randomly assigned 90 patients with ACI to receive arterial urokinase thrombolysis combined with Solitaire AB stent thrombectomy (observation group, OG) or to receive arterial urokinase thrombolysis (control group, CG). The two groups were compared in the National Institutes of Health Stroke Scale (NIHSS) score, activities of daily living (ADL) score, vascular recanalization rate 1 month after treatment, and serum levels of neuroprotective factors (insulin-like growth factor-I (IGF-1), neurotrophic factor (NTF), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF)) and factors for neurological injury (neuron-specific enolase (NSE), S100B protein (S100B), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP)) before treatment and the day after treatment.
resultsThe overall treatment response rate and vascular recanalization rate 1 month after treatment were markedly higher in OG than in CG (P<0.05). The NIHSS score decreased and the ADL score in both groups increased after treatment, with a lower NIHSS score and a higher ADL score in OG than in CG (all P<0.001). The difference in the complication rate between the two groups was not statistically significant (P>0.05). The day after treatment, serum levels of IGF-1, NTF, VEGF, and BDNF in both groups increased while levels of NSE, S100B, UCH-L1, and GFAP in them decreased, with higher levels of IGF-1, NTF, VEGF, and BDNF, and lower levels of NSE, S100B, UCH-L1, and GFAP in OG than in CG (all P<0.05).
conclusionArterial urokinase thrombolysis combined with Solitaire AB stent thrombectomy can enhance the treatment efficacy for ACI, stimulate the release of neuroprotective factors, and suppress the release of factors for neurological injury, without aggravating the treatment risk.
Indexed as
Identifiers
34017513PMC8129294W3163918916What OpenQuestion holds
Registered trials
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