ArticleAmerican journal of translational research2021
Clinical values of serum NGAL combined with NT-proBNP in the early prognosis of type 1 cardiorenal syndrome.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Review
- Diagnostic value and utility of commonly used biomarkers of cardiac and renal function in cardiorenal syndromes: a narrative review.Biochemia medica · 2023Review
- The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL).International journal of molecular sciences · 2023Review
- A comprehensive review of acute cardio-renal syndrome: need for novel biomarkers.Frontiers in pharmacology · 2023Review
- From heart failure and kidney dysfunction to cardiorenal syndrome: TMAO may be a bridge.Frontiers in pharmacology · 2023Review
- Association of plasma neutrophil gelatinase-associated lipocalin and thoracic aorta calcification in maintenance hemodialysis patients with and without diabetes.BMC nephrology · 2022Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiorenal syndrome (CRS) is a condition that defines disorders of the heart and kidneys whereby "acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other". Early diagnosis of its biomarkers has a significant impact on the treatment and prognosis of the CRS. Elevated serum NGAL and NT-proBNP levels are independent risk factors for predicting heart and kidney disease. Therefore, we proposed early detection of type 1 CRS using serum NGAL in combination with NT-proBNP.
objectiveThis study intended to investigate the clinical value of serum NGAL in combination with NT-proBNP in the early diagnosis of type 1 CRS.
methodsIn this paper, 80 patients with type 1 CRS and 80 healthy controls admitted to our hospital from January 2019 to August 2020 were retrospectively included, and the predictive value of single index and combined indices for predicting CRS were judged by calculating the correlation between serum NGAL, NT-proBNP and the creatinine levels and plotting receiver operating characteristic (ROC) curves.
resultsThere was no difference in baseline data between the control and patient groups. Serum NGAL and NT-proBNP in the patient group were significantly higher than those in the control group, and were positively correlated with changes in blood creatinine. The ROC curves showed that serum NGAL and NT-proBNP independently had a high predictive value for CRS, and the combination of the two had a better predictive value.
conclusionSerum NGAL in combination with NT-proBNP is of high clinical value for the early diagnosis of type 1 CRS.
Indexed as
Identifiers
34017511PMC8129259W3161944032What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.