ArticleAmerican journal of translational research2021
The inhibiting effects of microRNA-429 on the progression of pancreatic ductal adenocarcinoma cells by inhibiting epithelial mesenchymal transition.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The regulation of LRPs by miRNAs in cancer: influencing cancer characteristics and responses to treatment.Cancer cell international · 2025Review
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Authors and funding
2 authors.
Funding
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Abstract
objectiveTo research the effects and related mechanism of microRNA (miRNA)-429 in the development of pancreatic ductal adenocarcinoma (PDAC).
methodsThe proliferation and invasion ability of cells were evaluated through MTT assay and transwell assay, respectively. The expression of proteins and mRNA were examined by immunofluorescence, western blot, and quantitative real-time polymerase chain reaction (qRT-PCR).
resultsThe effects and potential mechanism of miR-429 in PDAC cells were explored and evaluated. Our study suggested that miR-429 is closely related with the progression of cancer. Overexpressed miR-429 restricted the mobility and proliferation of PDAC cells by restricting EMT, while down-regulated miR-429 had the opposite effect. These above results implied that miR-429 suppresses the development of PDAC by regulating EMT.
conclusionMiR-429 inhibits the progression of PDAC cells by regulating EMT. Our study provided a novel potential mechanism for the occurrence of PDAC and laid the foundation for the development of miRNA targeted therapy in patients with PDAC.
Indexed as
Identifiers
34017500PMC8129377What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.