ArticleAmerican journal of translational research2021
The clinical application value of miR-1269 as an unfavorable prognostic indicator of lung cancer.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- miR-1269a and miR-1269b: Emerging Carcinogenic Genes of the miR-1269 Family.Frontiers in cell and developmental biology · 2022Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThanks to microRNAs (miR), a myriad of outstanding achievements have been made in multiple fields in recent years. miR-1269, a newly discovered miR, presents high expression profiles in lung cancer (LC), but its clinical implications in LC have not been clarified yet.
methodsThe miR-1269 expressions in the peripheral blood of LC patients, benign pulmonary disease (BPD) patients, and healthy controls were measured using qRT-PCR. Receiver operating characteristic (ROC) curves were employed for the identification of the diagnostic value of miR-1269 in LC, as were Kaplan-Meier (K-M) analyses and a Cox regression model to determine miR-1269's prognostic value in LC.
resultsqRT-PCR revealed higher miR-1269 expressions in the LC patients than in the BPD patients and the controls (P < 0.001). The LC patients with high miR-1269 expressions had advanced tumor stages (III-IV) and an increased probability of lymph node metastasis (LNM) (P < 0.01). Also, evidently elevated miR-1269 levels were observed in the peripheral blood of patients with the advanced tumor stages (III-IV) and LNM. Via ROC curves, we found that miR-1269 is of high clinical significance in the diagnosis of LC and advanced tumor stages. Our K-M survival analysis revealed a lowered 5-year survival rate in patients with high miR-1269 expressions, and our Cox regression analysis found that miR-1269 is an independent prognostic factor for LC.
conclusionsmiR-1269, with high expression profiles in LC, indicates unfavorable patient prognoses, so it may be a viable diagnostic and prognostic indicator of LC.
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Identifiers
34017498PMC8129335W3162266571What OpenQuestion holds
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