ArticleAmerican journal of translational research2021
Long non-coding RNA H19 as a diagnostic marker in peripheral blood of patients with sepsis.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Is H19 RNA a Useful Marker of Acromegaly and Its Complications? A Preliminary Study.Biomedicines · 2023Article
- The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation.International journal of molecular sciences · 2023Review
- Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the diagnostic and prognostic value of circulating long non-coding RNA H19 (H19) in sepsis.
methodsA total of 104 septic patients admitted to our hospital from June 2018 to April 2019 were enrolled as the disease group, and another 92 healthy individuals were selected as the control group. The relative expression of H19 in peripheral blood was quantified by quantitative real-time polymerase chain reaction, and the diagnostic value in sepsis was assessed by receiver operating characteristic curve analysis. Pearson correlation coefficient was used to analyze the correlation between H19 and other inflammatory markers.
resultsCompared with the control group, the expression of peripheral blood H19 in the disease group was significantly down-regulated. The area under the curve (AUC) of H19 for diagnosing sepsis was 0.849. The expression of H19 in the survival group was significantly up-regulated compared with that in the death group, and the AUC in the survival group was 0.865. The relative expression of H19 was negatively correlated with PCT, CRP, IL-6, TNF-α, CK-MB, and cTnI. Multivariate logistic regression showed that patients with high lactic acid, coagulation dysfunction, high levels of PCT, CRP, IL-6, TNF-α, CK-MB, and cTnI, but low H19 expression had an increased risk of sepsis.
conclusionPeripheral blood H19 may be used for early diagnosis, clinical assessment, and prognosis of sepsis.
Indexed as
Identifiers
34017457PMC8129366W3161115859What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.