The effect of percutaneous drainage using tiny incisions on the inflammatory factors in chronic venous insufficiency combined with lipodermatosclerosis of the lower extremities.

Haihua Zhou, Zenghui Ma, Yan Li, Guofeng Lu, Boshun Wan

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Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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5 authors at 1 institution in 1 country.

Haihua ZhouDepartment of General Surgery, Affiliated Jiading Center Hospital of Shanghai University of Medicine & Health Science Shanghai 201800, China.

Zenghui MaDepartment of General Surgery, Affiliated Jiading Center Hospital of Shanghai University of Medicine & Health Science Shanghai 201800, China.

Yan LiDepartment of General Surgery, Affiliated Jiading Center Hospital of Shanghai University of Medicine & Health Science Shanghai 201800, China.

Guofeng LuDepartment of Pathology, Department of General Surgery, Affiliated Jiading Center Hospital of Shanghai University of Medicine & Health Science Shanghai 201800, China.

Boshun WanDepartment of General Surgery, Affiliated Jiading Center Hospital of Shanghai University of Medicine & Health Science Shanghai 201800, China.

Jiading District Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the efficacy of percutaneous drainage with tiny incisions in chronic venous insufficiency (CVI) combined with lipodystrophy syndrome (LDS) of the lower extremities and its effect on the inflammatory factors.

methodsSixty patients with CVI and LDS hospitalized for surgical treatment in Jiading District Central Hospital were recruited as the study cohort and randomly divided into a control group and an experimental group. The control group (n = 30) underwent varicose vein stripping in the lower extremities, while the experimental group (n = 30) was additionally treated with percutaneous drainage with tiny incisions for LDS. The efficacy of the two treatments, the mRNA expressions of collagen type I alpha 1 chain 1 (COL1A1), the lower limb circumferences, the subcutaneous thicknesses, the transcutaneous partial pressure of oxygen (TcPO

resultsThe total effective rate in the experimental group was 93.33% (28/30), which was higher than the rate of 73.33% (22/30) in the control group (

conclusionPercutaneous drainage with tiny incisions has a high efficacy for CVI with LDS, and it can relieve the condition, inhibit the expression of adhesion molecules as well as the inflammatory response, improve the microcirculation of the lower extremities, reduce COL1A1 expression, and improve the quality of life.

Indexed as

Chronic venous insufficiency in the lower extremitiesCOL1A1efficacyinflammatory responselipodystrophy syndrome

Identifiers

PMID34017423

PMCPMC8129386

OpenAlexW3160700820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.