ArticleAmerican journal of translational research2021
Diagnostic, monitoring, and prognostic value of combined detection of lactate dehydrogenase, β2-transferrin, and interleukin-10 for acute intracranial infections.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 1 citations in OpenAlex.
- Development and validation of a diagnostic nomogram for post-neurosurgical bacterial meningitis.BMC neurology · 2026Article
- Diagnostic and prognostic value of combined cerebrospinal fluid parameters for post-neurosurgical intracranial infection in brain tumor patients.Scientific reports · 2025Article
- Predictive value of cerebrospinal fluid heparin-binding protein and CD64 expression for postoperative central nervous system infection following intracerebral hemorrhage surgery.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the value of the combined detection of lactate dehydrogenase (LDH), β2-transferrin (β-2Tf), and interleukin-10 (IL-10) for identification of acute intracranial infections such as meningitis.
methodsA total of 103 patients were placed in the suppurative meningitis group (SMG), 124 patients in the viral meningitis group (VMG). Another 86 patients without any infectious diseases of the central nervous system constituted the control group (CG). The levels of LDH and β-2Tf in the cerebrospinal fluid were determined by enzymatic methods; IL-10 expression was measured by ELISA. The correlation between infection and the LDH, β-2Tf, and IL-10 levels was analyzed by linear correlation analysis, and ROC curve analysis was applied to determine the diagnostic value of combined detection of LDH, β-2Tf, and IL-10 levels for intracranial infections.
resultsLDH, β-2Tf, and IL-10 levels negatively correlated with the treatment time in both the SMG (r = -0.52, -0.97, and -0.24, respectively, P < 0.01) and VMG (r = -0.70, -0.91, and -0.25, respectively, P < 0.01). Sensitivity and specificity of combined detection of LDH, β-2Tf, and IL-10 for the diagnosis of SM was 80.47% and 75.33%, respectively, while those for VM were 84.24% and 79.24%, respectively.
conclusionCombined detection is an excellent indicator for the diagnosis and treatment of intracranial infections.
Indexed as
Identifiers
34017417PMC8129277W3161688928What OpenQuestion holds
Registered trials
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