Evidence map›Paper›PMID 34017328›Full record

ArticleFrontiers in immunology2021

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56

Johanna Euchner, Jasmin Sprissler, Toni Cathomen, Daniel Fürst, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Kerstin Felgentreff

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  5. From iPSC to manufactured iNK cells using CombiCult® screening platform.Frontiers in cell and developmental biology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Adoptive Cell Therapy from the Dish: Potentiating Induced Pluripotent Stem Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Review
  10. Article
  11. Review
  12. Article
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  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Good manufacturing practice production of CD34Cancer immunology, immunotherapy : CII · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Johanna EuchnerInstitute for Transfusion Medicine, Ulm University, Ulm, Germany.
Jasmin SprisslerInternational Graduate School in Molecular Medicine, Ulm University, Ulm, Germany.
Toni CathomenInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.
Daniel FürstInstitute for Transfusion Medicine, Ulm University, Ulm, Germany.
Hubert SchrezenmeierInstitute for Transfusion Medicine, Ulm University, Ulm, Germany.
Klaus-Michael DebatinDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Klaus SchwarzInstitute for Transfusion Medicine, Ulm University, Ulm, Germany.
Kerstin FelgentreffDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Universität Ulm · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and

Indexed as

CD56 AntigenCell Culture TechniquesCell DegranulationCell DifferentiationGPI-Linked ProteinsHumansInduced Pluripotent Stem CellsKiller Cells, NaturalLymphocyte ActivationLymphocyte SubsetsReceptors, IgGReceptors, KIR2DL2Receptors, KIR2DL3Receptors, KIR3DL1CD56 AntigenFCGR3B protein, humanGPI-Linked ProteinsKIR2DL2 protein, humanKIR2DL3 protein, humanKIR3DL1 protein, humanNCAM1 protein, humanReceptors, IgGReceptors, KIR2DL2Receptors, KIR2DL3Receptors, KIR3DL1hematopoietic progenitor cells (HPC)induced pluripotent stem cells (iPSC)natural killer (NK) cellsNK cell differentiationOP9-DL1

Identifiers

PMID34017328
PMCPMC8129508
OpenAlexW3158106454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.