ArticleFrontiers in endocrinology2021
Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 72 citations in OpenAlex.
- Prognostic significance of preoperative thyroid hormone sensitivity status for recurrence in papillary thyroid carcinoma.The oncologist · 2026Article
- Association between thyroid hormone sensitivity indices and renal function in community-dwelling euthyroid older adults: a cross-sectional study.Scientific reports · 2026Article
- Thyroid hormone sensitivity, insulin resistance and visceral fat area as determinants of prevalent coronary heart disease in euthyroid patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Association Between Thyroid Hormone Sensitivity Indicators and Controlled Attenuation Parameter (CAP) Values in Euthyroid Adults with Overweight/Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Thyroid autoimmunity is strongly associated with embryo quality in infertile euthyroid women receiving IVF/ICSI, especially patients with TSH values above 2.5 uIU/mL and poor ovarian response.BMC pregnancy and childbirth · 2025Article
- Effects of thyroid-stimulating hormone and sensitivity to thyroid hormones on the risk of hyperuricemia in euthyroid adults.Archives of endocrinology and metabolism · 2025Observational
- Genetic evidence links hyperthyroidism to knee osteoarthritis.Hormones (Athens, Greece) · 2025Article
- A Retrospective Analysis of the Changes in Prediabetes-Associated Markers of Thyroid Function in Patients from Durban, South Africa.International journal of molecular sciences · 2025Article
- Elevated mitochondrial DNA copy number in euthyroid individuals with impaired peripheral sensitivity to thyroid hormones.Frontiers in endocrinology · 2025Article
- Impaired thyroid hormone sensitivity is associated with the degrees of fatty infiltration in metabolic dysfunction associated steatotic liver disease.Frontiers in endocrinology · 2025Article
- Impaired sensitivity to thyroid hormones is positively associated to metabolic syndrome severity in euthyroid Chinese adults as revealed by a cross-sectional study.Frontiers in endocrinology · 2025Article
- Impaired sensitivity to thyroid hormones is associated with ASCVD risk factors in Beijing in euthyroid population: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study.Frontiers in endocrinology · 2025Article
- Association between impaired sensitivity to thyroid hormones and sedentary behavior: a cross-sectional study.Frontiers in medicine · 2025Article
- Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population.Frontiers in endocrinology · 2025Article
- Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old.International journal of medical sciences · 2025Article
- Associations of thyroid feedback quantile-based index with diabetes in euthyroid adults in the United States and China.Annals of medicine · 2024Article
- Correlation between thyroid hormone sensitivity and diabetic peripheral neuropathy in euthyroid patients with type 2 diabetes mellitus.Scientific reports · 2024Article
- Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007-2012.Clinical cardiology · 2024Article
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6 authors at 4 institutions in 1 country.
Funding
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Abstract
Context: Thyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones and prediabetes remains unknown. We aimed to investigate the association between thyroid hormones sensitivity and risk of prediabetes in both general and euthyroid populations. Methods: Participants with serum free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) measurements from the health checkup programs of the First Hospital of China Medical University were collected. We measured the parameters representing central and peripheral sensitivities to thyroid hormones (central sensitivity, assessed by calculating Thyroid Feedback Quantile-based Index (TFQI), TSH Index (TSHI), and Thyrotroph Thyroxine Resistance Index (TT4RI); peripheral sensitivity, evaluated by FT3/FT4 ratio). Associations between thyroid hormones sensitivities and risk of prediabetes were assessed with logistic regression. Results: A total of 4378 participants (mean age ± SD, 49 ± 11 years) were included, with 1457 (33%) subjects had prediabetes. The risk of prediabetes was negatively associated with levels of TSHI (odds ratio [OR] 0.91; 95% confidence interval [CI], 0.85-0.97), TT4RI (OR 0.91; 95% CI, 0.84-0.99) and Parametric TFQI (PTFQI) (OR 0.89; 95% CI, 0.83-0.95) among all subjects. The association remained significant in euthyroid subjects and euthyroid subjects with negative thyroid autoimmunity. Higher FT3/FT4 ratio was associated with a mild increased risk of prediabetes (95% CI 1.09; 1.02-1.16). Compared with subjects in the lowest quartile of PTFQI, those in the highest quartile had lower risk of prediabetes (0.70; 95% CI, 0.58-0.84). Conclusions: Decreased central sensitivity to thyroid hormones is associated with lower risk of prediabetes. This demonstrates the complex interaction between thyroid system and glucose metabolism. Future studies are warranted to confirm our findings and underlying mechanisms.
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