Evidence map›Paper›PMID 34017310›Full record

ArticleFrontiers in endocrinology2021

Erectile Dysfunction Is Associated With Excessive Growth Hormone Levels in Male Patients With Acromegaly.

Zhengyuan Chen, Xiaoqing Shao, Min He, Ming Shen, Wei Gong, Meng Wang, Yichao Zhang, Wenjuan Liu, Zengyi Ma, Zhao Ye and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Zhengyuan ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoqing ShaoDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Min HeDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Ming ShenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Wei GongDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Meng WangDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yichao ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Wenjuan LiuDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zengyi MaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhao YeDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yongning LuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Nianqin YangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shanwen ChenDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Lydia HuDepartment of Biochemistry and Cellular and Molecular Biology, College of Arts and Sciences, The University of Tennessee, Knoxville, Knoxville, TX, United States.
Yiming LiDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yongfei WangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yao ZhaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhaoyun ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CNKnoxville College · USShanghai Clinical Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine the risk factors for erectile dysfunction (ED) in male patients with acromegaly and to prospectively investigate the short-term changes of erectile function after surgery or medical treatment. Methods: Sixty-three male patients were subjected to nocturnal penile tumescence and rigidity (NPTR) test for the evaluation of erectile function. The measurement of serum nitric oxide (NO) was also performed. Twenty-seven patients were re-evaluated by NPTR after surgery or long-term somatostatin analogues (SSA) treatment. Results: Twenty-two patients (34.9%) had ED. Patients with ED showed higher random GH (17.89 [10.97-44.19] μg/L Conclusions: Excessive GH is related to ED in male patients with acromegaly. GH normalization after treatment is beneficial for short-term erectile function recovery.

Indexed as

AcromegalyAdenomaAdultEndoscopyErectile DysfunctionGlucose Tolerance TestHuman Growth HormoneHumansInsulin-Like Growth Factor IMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNitric OxidePenile ErectionProspective StudiesHuman Growth HormoneInsulin-Like Growth Factor INitric OxideSomatostatinacromegalyerectile dysfunctionGH suppressionNPTR assessmentsexual dysfunction

Identifiers

PMID34017310
PMCPMC8129559
OpenAlexW3157525505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.