Evidence map›Paper›PMID 34017139›Full record

ReviewNature reviews. Cardiology2021

Sit less and move more for cardiovascular health: emerging insights and opportunities.

David W Dunstan, Shilpa Dogra, Sophie E Carter, Neville Owen

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 6 pooled it
29.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 6 syntheses or guidelines pooled it, 319 citations in OpenAlex.

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  11. Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors.The international journal of behavioral nutrition and physical activity · 2024
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  19. Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

David W DunstanPhysical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. david.dunstan@baker.edu.au.ORCID http://orcid.org/0000-0003-2629-9568
Shilpa DograFaculty of Health Sciences (Kinesiology), University of Ontario Institute of Technology, Oshawa, Ontario, Canada.
Sophie E CarterSchool of Science, Technology and Health, York St John University, York, UK.
Neville OwenBehavioural Epidemiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-2784-4820
Baker Heart and Diabetes Institute · AUOntario Tech University · CAYork St John University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sedentary behaviour - put simply, too much sitting, as a distinct concept from too little exercise - is a novel determinant of cardiovascular risk. This definition provides a perspective that is complementary to the well-understood detrimental effects of physical inactivity. Sitting occupies the majority of the daily waking hours in most adults and has become even more pervasive owing to the COVID-19 pandemic. The potential for a broad cardiovascular health benefit exists through an integrated approach that involves 'sitting less and moving more'. In this Review, we first consider observational and experimental evidence on the adverse effects of prolonged, uninterrupted sitting and the evidence identifying the possible mechanisms underlying the associated risk. We summarize the results of randomized controlled trials demonstrating the feasibility of changing sedentary behaviour. We also highlight evidence on the deleterious synergies between sedentary behaviour and physical inactivity as the underpinnings of our case for addressing them jointly in mitigating cardiovascular risk. This integrated approach should not only reduce the specific risks of too much sitting but also have a positive effect on the total amount of physical activity, with the potential to more broadly benefit the health of individuals living with or at risk of developing cardiovascular disease.

Indexed as

ExerciseRisk Reduction BehaviorSedentary BehaviorSitting PositionCardiovascular DiseasesCOVID-19Evidence-Based MedicineHeart Disease Risk FactorsHumansRandomized Controlled Trials as TopicRisk AssessmentTime Factors

Identifiers

PMID34017139
OpenAlexW3161942044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.