Evidence map›Paper›PMID 34017124›Full record

Observational studyNature immunology2021

Clonally expanded EOMES

Raoul J P Bonnal, Grazisa Rossetti, Enrico Lugli, Marco De Simone, Paola Gruarin, Jolanda Brummelman, Lorenzo Drufuca, Marco Passaro, Ramona Bason, Federica Gervasoni and 36 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  6. EomesoderminImmunity · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. CD4Trends in cancer · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 14 institutions in 2 countries.

Raoul J P Bonnal *Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.ORCID 0000-0002-2123-6536
Grazisa Rossetti *Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Enrico Lugli *Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID 0000-0002-1964-7678
Marco De Simone *Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Paola Gruarin *Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Jolanda Brummelman *Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID 0000-0003-3581-4816
Lorenzo DrufucaIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Marco PassaroIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Ramona BasonIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Federica GervasoniIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Giulia Della ChiaraIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.ORCID 0000-0001-5211-3814
Claudia D'OriaIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Martina MartinovicIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Serena CurtiIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Valeria RanzaniIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Chiara CordiglieriIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Giorgia AlvisiLaboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Emilia Maria Cristina MazzaLaboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID 0000-0003-2424-3640
Stefania OlivetoIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Ylenia SilvestriIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Elena CarelliIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Saveria MazzaraDivision of Hematopathology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Roberto BosottiIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Maria Lucia SarnicolaIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Chiara GodanoIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Valeria BevilacquaIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Mariangela LorenzoIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Salvatore SienaNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Emanuela BonoldiPathology and Cytogenetics Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Andrea Sartore-BianchiNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.ORCID 0000-0003-0780-0409
Alessio AmatuNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.ORCID 0000-0001-5396-3378
Giulia VeronesiFaculty of Medicine and Surgery Vita-Salute San Raffaele University, Milan, Italy.
Pierluigi NovellisDivision of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marco AlloisioDivision of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Alessandro GianiDepartment of Surgery, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.ORCID 0000-0003-0718-2321
Nicola ZucchiniDepartment of Pathology, San Gerardo Hospital, Monza, Italy.
Enrico OpocherUnità Operativa Chirurgia Epatobiliopancreatica e Digestiva, Ospedale San Paolo, Milan, Italy.
Andrea Pisani CerettiUnità Operativa Chirurgia Epatobiliopancreatica e Digestiva, Ospedale San Paolo, Milan, Italy.
Nicolò MarianiUnità Operativa Chirurgia Epatobiliopancreatica e Digestiva, Ospedale San Paolo, Milan, Italy.ORCID 0000-0003-4360-187X
Stefano BiffoIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.ORCID 0000-0002-3780-1050
Daniele PratiDepartment of Transfusion Medicine and Hematology, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-2281-7498
Alberto BardelliCandiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia-IRCCS, Turin, Italy.
Jens GeginatIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy. geginat@ingm.org.ORCID 0000-0003-4813-0384
Antonio LanzavecchiaIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy. lanzavecchia@ingm.org.ORCID 0000-0002-3041-7240
Sergio AbrignaniIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy. abrignani@ingm.org.ORCID 0000-0002-0794-3285
Massimiliano PaganiIstituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy. massimiliano.pagani@ifom.eu.ORCID 0000-0002-7017-9304
Istituto Nazionale Genetica Molecolare · ITIFOM · ITUniversity of Milan · ITIRCCS Humanitas Research Hospital · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITOspedale San Paolo · ITVita-Salute San Raffaele University · ITAzienda Ospedaliera San Gerardo · ITCandiolo Cancer Institute · ITCedars-Sinai Medical Center · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHumanitas University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Milano-Bicocca · IT

Funding

Cancer Research UK 22794Cancer Research UK 26813
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

AdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCell DifferentiationCell ProliferationChemotherapy, AdjuvantChitinasesClonal HematopoiesisColectomyColonColorectal NeoplasmsDatasets as TopicDisease ProgressionDrug Resistance, NeoplasmFemaleCHI3L2 protein, humanChitinasesEOMES protein, humanForkhead Transcription FactorsFOXP3 protein, humanGranzymesGZMK protein, humanImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorT-Box Domain Proteins

Identifiers

PMID34017124
OpenAlexW3161655951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.