Evidence map›Paper›PMID 34017106›Full record

ArticleNature microbiology2021

Tracking bacterial lineages in complex and dynamic environments with applications for growth control and persistence.

Somenath Bakshi, Emanuele Leoncini, Charles Baker, Silvia J Cañas-Duarte, Burak Okumus, Johan Paulsson

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 120 citations in OpenAlex.

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  14. TrackRefiner a tool for refinement of bacillus cell tracking data.NPJ systems biology and applications · 2025
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  16. Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
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  20. A link between aging and persistence.Antimicrobial agents and chemotherapy · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Somenath Bakshi *Department of Systems Biology, Harvard Medical School, Boston, MA, USA. somenath.bakshi@eng.cam.ac.uk.
Emanuele Leoncini *Department of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5387-118X
Charles BakerBiophysics Program, Harvard University, Boston, MA, USA.
Silvia J Cañas-DuarteDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5705-0023
Burak OkumusDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Johan PaulssonDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA. Johan_Paulsson@hms.harvard.edu.ORCID http://orcid.org/0000-0002-8671-4914
Harvard University · US

Funding

A general mechanism of persister formationR01AI141966 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM, PAULSSON, JOHAN · 2019 to 2022
$2.9M
NIAID NIH HHS R01 AI141966
6 · The paper itself

Abstract

As bacteria transition from exponential to stationary phase, they change substantially in size, morphology, growth and expression profiles. These responses also vary between individual cells, but it has proved difficult to track cell lineages along the growth curve to determine the progression of events or correlations between how individual cells enter and exit dormancy. Here, we developed a platform for tracking more than 10

Indexed as

Anti-Bacterial AgentsBacillus subtilisCulture MediaEscherichia coliAnti-Bacterial AgentsCulture Media

Identifiers

PMID34017106
PMCPMC10277933
OpenAlexW3162666452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.